In postmortem investigations of fatal intoxications it is often challenging to determine which drug/s caused the death. To improve the interpretation of postmortem blood concentrations of sedative and hypnotic drugs and/or clonazepam, all medico-legal autopsies in Sweden - where these drugs had been detected in femoral vein blood during 1992-2006 - were identified in the databases of the Nation...

BACKGROUND Although therapeutic drug monitoring (TDM) is considered an underused tool in psychiatric care, the prevalence of TDM is largely unknown. The aim of this study was to analyze the prevalence of TDM for antidepressants and antipsychotics during 2006-2013. METHODS The study population consisted of individuals ≥5 years of age residing in Stockholm County. The prevalence of TDM for each...

The aim of the research was to study possible therapeutic effect "Argitos" in form a spray and liquid Pyridine-2-carboxaldehyde (Tryptophan2PKA) thermal burns. Studies have shown that levels blood parameters groups burn + (spray) (intraperitoneal injection -IP) differ from control group (pure burn). With IP administration tryptophan- 2PKA, tendency towards normalization higher efficiency were o...

spinal cord injury (sci) leads to a significant health problem associated with a broad range of secondary complications and disabilities. in this regard, animal models can help us to understand the pathobiology of sci and evaluate the effects of potential treatments for sci. in contusion models of sci, different devices including surgical spring-loaded clips, balloons, forceps, weights and the ...

concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. although these recommendations are not specific to children, the values can be extrapolated. this prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...

background: since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. this study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. methods: nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°c/min) ...

colorectal cancer is one of the most prevalent cancers in the world. it's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. to improve and standardize the treatment modalities in this field, much rese...

BACKGROUND This article describes the retrospective analysis of the patients who presented with a drug-related intoxication to the emergency department of the Erasmus Medical Centre in 2000. METHODS Data were collected from the emergency department's electronic database and the medical charts of the patients. RESULTS A total of 243 patients were seen with a drug-related intoxication caused ...

Neurodegenerative disorders and diseases (NDDs) that are either chronically acquired or triggered by a singular detrimental event are a rapidly growing cause of disability and/or death. In recent times, there have been major advancements in our understanding of various neurodegenerative disease states that have revealed common pathologic features or mechanisms. The many mechanistic parallels di...

The medical disorder known as hyperlipidemia is characterized by unusually high amount of lipids in the blood (fatty substances). This illness also associated with being overweight. Even though hypolipidemic drugs are commonly used to treat cardiovascular diseases and stroke, there a possibility that they may cause undesirable side effects. Many different medicinal plants have been successfully...