A Fe-TAML/H2O2 catalytic oxidation process achieves facile in-solution total degradation of fenitrothion and two other organophosphorus (OP) pesticides. Degradation products have been identified and quantified providing evidence for oxidative hydrolysis, oxidative desulfuration, perhydrolysis, and deep oxidation. Degradation pathways can be selected by pH control to completely obviate all toxic...

Dapiprazole (DPZ) was subjected to different stress conditions prescribed by the International Conference on Harmonization. A stability-indicating high-performance liquid chromatography method was developed for the analysis of the drug in the presence of its degradation products. The degradation was found to occur in hydrolytic, and to some extent, photolytic conditions, however, the drug was s...

The high performance liquid chromatographic method was developed for the determination of Rasagiline Mesylate in presence of its degradation products. As per the ICH guidelines Q1A (R2), forced degradation study was carried out under oxidative, photolytic and thermal stress conditions. The analysis of stressed samples was carried out using Prontosil C18 column. The mobile phase comprised of met...

A novel, reversed-phase ultra-performance liquid chromatographic method was developed and validated for the determination of related substances in Naproxen (NAP) bulk drugs and dosage forms. The related substances included degradation and process-related impurities. The method was developed using the Waters Acquity BEH C18 column using the gradient program with mobile phase A of a pH 7.0 phosph...

In this work, the chemical and thermal stability of a primary amine-functionalized ion-exchange resin (Lewatit VP OC 1065) is studied in view of the potential options of regenerating this sorbent in a CO2 removal application. The adsorbent was treated continuously in the presence of air, different O2/CO2/N2 mixtures, concentrated CO2, and steam, and then the remaining CO2 adsorption capacity wa...

In this study a simple and efficient stability-indicating HPLC method with short run time was developed for the determination of nitisinone. The stress degradation of nitisinone was studied in different acidic, basic, oxidative, thermal and photolytic conditions. The chromatographic separation was achieved on a Nova-Pak C18 column using a mixture of 50 mM NaH2PO4 (pH 2.5) and acetonitrile (45:5...

Two sensitive, precise and cost-effective UV-spectrophotometric methods are described for the determination of terbinafine hydrochloride (TFH) in bulk drug and tablets. The methods are based on the measurement of absorbance of TFH in 0.1M HCl at 222 nm in method A and in 0.1M acetic acid at 282 nm in method B. As per the International Conference on harmonization ICH guidelines, the methods were...

Method development for synthetic peptide molecules is often a challenging task as peptides get easily degraded in mild stress conditions and also offer chromatographic challenges like carryover, loss during run adsorption of the drug onto walls storage container. This article presents an easy, accurate reproducible stability-indicating, mass compatible Reverse Phase-Liquid Chromatographic metho...

A validated specific stability indicating reversed-phase liquid chromatographic method was developed for the quantitative determination of Aripiprazole and its related substances in bulk samples, pharmaceutical dosage forms in presence of degradation products. Forced degradation studies were performed on bulk sample of Aripiprazole as per ICH prescribed stress conditions using acid, base, oxida...