Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was a...

To the Editor:—In their very interesting study, Loop et al. demonstrate an inhibitory effect of thiopental on nuclear factor B (NFB) activation in T cells. However, we missed some essential background information in the discussion. First, the concentration of thiopental used in this study is much higher than plasma concentrations noted in clinical practice or in other models presenting inhibito...

A gaschromatographic method is presented for the determination of thiopental (and of its metabolite pentobarbital) in cases of severe head injuries treated by induction of therapeutic barbiturate coma. To 1 ml serum the internal standard and saturated ammonium sulphate solution are added. The mixture is extracted by chloroform and the concentrated organic phase is injected into the gaschromatog...

Few studies have dealt with thiopental sodium-induced anaesthetic action and the effect of combining meloxicam (a high plasma protein-bound) in 10–15 day old chicks. First, analgesic median effective dose (ED50) was determined as 35.85 mg/kg, IM by up-and-down routine, while hypnotic ED50 value 34.40 chick model. A sodium injection (18, 36 72 IM) produces a significant dose-responsive chicks, b...

The phenomenon of "acute tolerance" to thiopentone was re-examined in 82 subjects with induction doses of 2-15mg kg-1. There was a strong positive correlation between the venous plasma thiopentone concentrations on recovery from anesthesia and the induction dose, expressed as either mg kg-1 or mg m-2. Recovery time was proportionately shorter with larger doses, being directly related to log10 o...

background: electroconvulsive therapy (ect) is usually given to people with severe depression which has not responded to other forms of treatment such as anti-depressants. ect may be accompanied by potentially significant medical complications including prolonged seizures, prolonged apnea, or cardiac or pulmonary complications. modification of ect with brief anesthesia and muscle relaxants shou...

Several studies suggest that anesthetics modulate the immune response. The aim of this study was to investigate the effect of halothane and thiopental on the lung inflammatory response. Rats submitted or not to intratracheal (IT) instillation of lipopolysaccharides (LPS) were anesthetized with either halothane (0. 5, 1, or 1.5%) or thiopental (60 mg. kg(-1)) and mechanically ventilated for 4 h....

OBJECTIVE To compare the effects of propofol and thiopental on haemodynamics, awareness and newborns in pregnant women undergoing elective caesarean section. METHODS Seventy pregnant women were assigned into two equal groups. For anaesthesia induction, 2 mg kg(-1) propofol (Group P) and 5 mg kg(-1) thiopental (Group T) were administered. Maternal haemodynamic parameters and bispectral index (...