The chelator di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) shows potent and selective anticancer and antimetastatic activity. However, the mechanism by which it is initially transported into cells to induce cytotoxicity is unknown. Hence, the current investigation examined the cellular uptake of ¹⁴C-Dp44mT relative to two structurally related ligands, namely the aroylhydrazone ¹⁴...

2, 4-Dihydroxy-5-Bromo-[2’methyl]-Propiophenone thiosemicarbazone [DHBMPT] has been used for the spectrophotometric determination of Pd(II) at pH = 2.5. Job’s method of continuous variation and Yoe and Jones Mole ratio method show metal: ligand ratio in the complex to be 1:1. The molar absorptivity of complex at 390 nm was found to be 1.457 x10 lit.mol.cm and Sandell’s sensitivity was found to ...

BACKGROUND Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), demonstrates promising anti-tumor activity. Recently, a second-generation analogue, namely di-2-pyridylketon...

Reaction of readily available 2-formyl -1-methyl-5-nitroimidazole (1) with 4-substituted-2-hydrazinothiazoles (2) afforded 2-formyl-l-methyl-5- nitroimidazole 4-substituted -2- thiazolylhydrazones (3). Reaction of thiochromitn-4-one (4) with thiosemicarbazide gave thiochroman-4- one thiosemicarbazone (5). Reaction of compound 5 with clc- haloaldehyde or ketones y ielded thiochroman--#-one ...

a Faculty of Biotechnology and Food Chemistry, Lodz University of Technology, Stefanowskiego Street 4/10, 90-924 Lodz, Poland b Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal c Dipartimento di Chimica e Farmacia, Università di Sassari, via Vienna 2, I-07100 Sassari, Italy d Centro de Ciências e Tecnologias Nucleares,...

A rapid and sensitive extractive spectrophotometric method has been developed for the determination of palladium(II) in synthetic mixtures and hydrogenation catalysts using pyridoxal-4-phenyl-3-thiosemicarbazone (PPT) as an analytical reagent. The reagent forms a red-color complex with the metal at pH 3.0, which is extracted into benzene. The absorbance is measured at 460 nm. The method adheres...

Thiosemiccarbozones are having enormous medicine applications due to the presence of hetero atom nitrogen and sulfur in its molecular structure. The carbonyl compounds also largest clinical cure many diseases. We merged these two classes organic their substitution by solution growth techniques crystal tested as antibiotic against few fastidious non gram +ve –ve organisms. Ortho substituted para...