INTRODUCTION Differential diagnosis of thrombotic microangiopathies can be difficult. Atypical hemolytic uremic syndrome is a rare, life-threatening disease caused by uncontrolled chronic activation of alternative complement pathway, resulting in microvascular thrombosis, organ ischemia and damage. Prognosis is poor: up to 65 percent of patients require dialysis or have kidney damage of varying...

0ver the past 30 years, heparin has become the drug most commonly used to treat a variety of acute thrombotic disorders. Heparin reduces the incidence of recurrence while causing relatively few adverse reactions. However, the protection afforded by heparin against recurrent thrombosis is not complete, and the amount of the drug which can be administered is limited by the risk of serious bleedin...

Two novel methods of Modulated-Temperature Thermal Analysis are described. These are loosely-termed `̀ Constrained Rate DSC'' and `̀ Modulated-Temperature TMA''. In the ®rst, the sample response is used to control the temperature program of a DSC in a method analogous to Controlled Rate Thermal Analysis. This results in a temperature modulation which is variable in period, amplitude and underlyin...

Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.

Mark S. Indelicato 2012 TMA Chairman Hahn & Hessen LLP Gregory J. Fine, CAE TMA Chief Executive Officer Ronald R. Sussman 2012 TMA President Cooley LLP Certification Program Capping months of discussion, TMA amended its bylaws in April 2012 to fully integrate the Certified Turnaround Professional (CTP) program into TMA. The amendments followed agreement between the leadership of the Certificati...

Deposition of thrombotic material on catheters was observed following more than 50% of 93 diagnostic catheterizations. The incidence of deposition of thrombotic material on catheters remaining in the body for more than 1 day was 100%. Polyethylene and siliconized polyurethane catheters were less thrombogenic than Teflon end-occluded catheters. A definite time relationship between the thrombus f...

Experiments on rats indicate that thrombosis of large veins can develop while blood coagulability is decreased. Hence, coagulation tests have only a limited value in predicting a thrombotic tendency, although they do show characteristic changes during the formation of thrombi.