Purpose: The study aimed to evaluate the effect of thymoquinone on cardiac tissue in MTX-induced toxicity rats with various parameters.
 Materials and Methods: Group I (n:8) was administered intraperitoneal saline for 10 days. Intraperitoneal olive oil applied II III a single dose 20 mg/kg Methotrexate (MTX) (500 mg/20 ml) intraperitoneally 1st day experiment. Since liquid form, no solvent...

Purpose: The aim of this study was to evaluate histologically and immunohistochemically the cytoprotective effects thymoquinone (THQ) against isoproterenol (ISO)-induced aortic tissue damage.
 Materials Methods: Rats were divided into four groups (n=8). Control group (Control); untreated rats, Thymoquinone (THQ); 20 mg / kg intragastrically (ig) THQ at 24 hour intervals for 8 days, Isoprot...

background: nigella sativa has been a nutritional flavoring factor and natural treatment for many ailments for so many years in medical science. earlier studies have been reported that thymoquinone (tq), an active compound of its seed, contains anticancer properties. previous studies have shown that tq induces apoptosis in breast cancer cells but it is unclear the role of p53 in the apoptotic p...

Quinones are plant-derived secondary metabolites that present some anti-proliferation and anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone. We intend to summarize their anti-cancer effects and investigate the mechan...

nigella sativa (n. sativa), which belongs to the botanical family of ranunculaceae, is a widely used medicinal plant all over the world. n. sativa seeds and oil have been used in the treatment of different diseases. various studies on n. sativa have been carried out and a broad spectrum of its pharmacological actions have been established which include antioxidant, antidiabetic, anticancer, ant...

this study was conducted to assess the effects of irrigation and plant growth promoting bactera on seed yield and qualitative characteristics of black cumin (nigella sativa l.) at the experimental station of the research institute of forest and rangeland, damavan region, iran. a split-plot experimental design, based on randomized complete block design (rcbd) with three replications, was used. i...

Background and Objectives Alzheimer's disease (AD) is the most common form of dementia among older persons. Thymoquinone (TQ) has anti-inflammatory, anticonvulsant and antioxidant activity. A novel α7 nicotinic acetyl choline receptor (α7 nAChR ) agonist (PNU- 282987) have been identified to enhance the cognitive performance. An alternative treatment strategy via compounds known as nicotinic "p...

Supercritical fluid extraction (SFE) of the volatile oil from Thymus vulgaris L. aerial flowering parts was performed under different conditions of pressure, temperature, mean particle size and CO(2) flow rate and the correspondent yield and composition were compared with those of the essential oil isolated by hydrodistillation (HD). Both the oils were analyzed by GC and GC-MS and 52 components...

OBJECTIVE To investigate potential mechanisms mediating the neuroprotective effect of thymoquinone (TQ) on dopaminergic neurons. METHODS This study was conducted in the Chemistry and Biochemistry Institute, University of Veterinary Medicine, Vienna, Austria between June and August 2013. Primary cultures were prepared from embryonic mouse mesencephala (OFI/SPF) at gestation day 14. Four sets o...

This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), (Bcl-2), caspase 3, mammalian target rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), kinase B (AKT) gene expr...