Congenitally thymusless nude mice that lacked functional T cells were reconstituted with H-2-compatible or -incompatible thymus grafts taken from either fetal, newborn, or adult mice and transplanted under the kidney capsule or subcutaneously. Transplantation with unirradiated fetal (15--17 d) or newborn thymus grafts reconstituted the nude mice as assessed by their subsequent generation of vir...

Background & Objective: The thymus gland significantly affects fetal immune system maturation. Additionally, there is a linear association between size and its performance. Given the high prevalence of vitamin D deficiency in Iran scarce studies with conflicting results, subjecting maternal concentration effect on thymus, we decided to investigate relation mid-gestation. This study also aimed g...

Maintenance of the peripheral T-cell pool throughout the life requires uninterrupted generation of T cells. The majority of peripheral T cells are generated in the thymus. However, the thymus does not contain hematopoietic progenitors with unlimited self-renewing potential, and continuous production of T cells requires importation of such progenitors from the bone marrow into the thymus. Thymus...

The endodermal epithelial thymus anlage develops in tight association with neural crest (NC)-derived mesenchyme. This epithelial-NC interaction is crucial for thymus development, but it is not known how NC supports thymus development or whether NC cells or their progeny make any significant contribution to the adult thymus. By nude mouse blastocyst complementation and by cell surface phenotype,...

Thymic lymphocytes are continuously replaced by stem cells entering the thymus. The thymus of animals receiving lethal total body irradiation, followed by administration of bone marrow or spleen cells, is repopulated by cells derived from the inoculure (1-6). Similarly, repopulation of the unirradiated thymus eventually occurs in animals in which only the lower third of the body was irradiated ...

From the facts stated in this paper it is evident that the thymus gland of mammals contains a substance which is capable of producing tetany when fed to the larvae of certain species of salamanders (Ambystoma opacum and Ambystoma maculatum). As long as the larvae have not developed their own thymus glands, they are able, by means of some mechanism, to counterbalance the tetanic action of the th...

Therapeutic Effect of Thyme (Thymus Vulgaris) Essential Oil on Patients with COVID19: A Randomized Clinical Trial

LTHOUGH the thymus has been proved to play an essential role in the development and maintenance of immune reactivity, the mechanisms by which it exerts these functions are still to be elucidated. While significant titers of antibody”2 or plasma cell accumulation3’4 have not been detected in the intact thymus of animals given antigens at distant site, histologic signs indicative of local antibod...

Irradiated and thymectomized CBA mice are markedly depressed in several immunological parameters (skin homograft rejection, graft-vs.-host activity and hemolytic plaque-forming cells of the spleen, hemolysin and hemagglutinin formation, and peripheral lymphocyte counts). In the present experiments the ability of homografts of neonatal thymus placed beneath the kidney capsule to restore immunolo...

LTHOUGH the thymus has been proved to play an essential role in the development and maintenance of immune reactivity, the mechanisms by which it exerts these functions are still to be elucidated. While significant titers of antibody”2 or plasma cell accumulation3’4 have not been detected in the intact thymus of animals given antigens at distant site, histologic signs indicative of local antibod...