Purpose: This study aims to investigate the effects of experimental hyperthyroidism and carnosine which is known have antioxidant properties on physical vital findings in rats, determine relationship between these parameters free T3 (FT3) levels.
 Materials Methods: Rats were analyzed 7 groups (each containing 12 animals); control (CONT), hyperthyroidism-1 (T:10-day L-thyroxine (L-T4) admi...

BACKGROUND & OBJECTIVES There is scarcity of information on impact of iodine deficiency on growth and development of newborns, both pre-term and term babies. The present study was carried out to see the impact of iodine deficiency (ID) on the intrauterine foetal growth and development in terms of birth weight (BW) in an African population living in an iodine deficient zone. METHODS The matern...

Congenital hypothyroidism (CH) is one of the most common endocrine disorders in the infant population. It is also one of the most important causes of foreseeable brain damage and severe mental impairment. Current views on CH pathogenesis, screening schema and treatment standards have been presented. Also outlined have been the newest reports on the impact on CH epidemiology and classification g...

The plasma triiodothyronine (T3) and thyroxine (T4) ratios have been evaluated in kwashiorkor and diet-induced obese weaned rats. The concentrations of T3 and T4 were determined in plasma by radio-immunoassay. A significant decrease in T3 level in the order kwashiorkor < obese < control was observed. However T4 concentration was more elevated (P < 0.01) in the obese than the normal controls, wh...

Serum free thyroxine (FT4), total T4 (T4) and total T3 (T3) were determined by radioimmunoassay in 1,114 adults during a periodic health evaluation to detect unsuspected thyroid dysfunction. As a result, 3 patients with hyperthyroidism, 4 with hypothyroidism, 3 taking thyroid medication, 4 with chronic thyroiditis, 1 with simple goiter and 3 women under estrogen administration were found. Free ...

To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL). Twenty-seven patients with one or more abnormal thyroid hormone results were further investigated by...

The development of anaemia is a major pathological manifestation in chronic trypanosomosis. The anaemia in African trypanosomosis coincides with a marked decrease in plasma concentration of both thyroxine (T4) and 3,5,3' triiodothyronine (T3). To evaluate the effect of trypanosome-induced hypothyroidism on the development of anaemia, sexually mature white New Zealand rabbits were used. Three gr...

To evaluate the effect of long-term clomipramine administration on the hypothalamic-pituitary-thyroid axis in healthy dogs, 14 healthy adult dogs were enrolled in a prospective study. Clomipramine (3 mg/kg PO q12h) was administered to all dogs beginning on day 0, and continued for 112 days. Serum total thyroxine (T4), free thyroxine (fT4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine ...

Levels of thyroid hormones, serum thyroxine, triiodothyronine (T3), free thyroxine (FT4), free triiodothyronine (FT3) and thyrotropin (TSH) were measured in 55 patients with liver cirrhosis using radioimmunoassay techniques. Results were compared with 78 controls. The mean serum concentration of T3, FT3 and FT4 were significantly decreased in cirrhotics, while no significant change was noted in...