Objective: To explore the mechanical properties, biological activity, and osteogenic ability of 3D printed TC4 titanium (Ti) alloy dental implants treated with surface modification. Methods: Dental 30% porosity were manufactured using selective laser melting (SLM) technology (group 3D), while traditional numerically-controlled machine tools (CNC) used to manufacture without SL). The then modifi...

The surface of a biomaterial interacts with the body fluid upon implantation in the human body. The biocompatibility of a material is strongly influenced by the adsorption of proteins onto the surface. Titanium is frequently used as a biomaterial for implants in orthopedics and cardiovascular devices. Understanding the biocompatibility is very important to improve implants. The surface chemistr...

Titanium-based implants have been widely used in orthopedic surgery; however, failures still occur. Our in vitro study has demonstrated that gentamicin-loaded, 80 nm-diameter nanotubes possessed both antibacterial and osteogenic activities. Thus, the aim of this study was to further investigate the in vivo anti-infection effect of the titanium implants with gentamicin-loaded nanotubes. Thirty-s...

Formation of bacterial biofilms on dental implant material surfaces (titanium) may lead to the development of peri-implant diseases influencing the long term success of dental implants. In this study, a novel Cu-bearing titanium alloy (Ti-Cu) was designed and fabricated in order to efficiently kill bacteria and discourage formation of biofilms, and then inhibit bacterial infection and prevent i...

Titanium (Ti) implants with enhanced biocompatibility and antibacterial property are highly desirable and characterized by improved success rates. In this study, titania nanotubes (TNTs) with various tube diameters were fabricated on Ti surfaces through electrochemical anodization at 10, 30, and 60 V (denoted as NT10, NT30, and NT60, resp.). Ti was also investigated and used as a control. NT10 ...

The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined...

Ti-based bulk metallic glasses are of great interest in biomedical applications due to their high corrosion resistance, excellent mechanical properties and good biocompatibility. This article reviews recent progress in the development of Ti-based metallic glasses for the application as biomaterials. Ti-based (Ti­Zr­Cu­Pd, Ti­Zr­Cu­Pd­Sn, and Ti­Zr­Cu­Pd­Nb) bulk metallic glasses without toxic a...

Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of ...

The aim of the study was to compare the connective tissue response of Lewis rats to Ti, NiCr and AgPd alloys. It was found that implants were covered by collagen-rich, well vascularized capsules. Titanium was covered by the thinnest capsule (57 ± 20 μm) and AgPd alloy was covered by the thickest capsule (239 ± 50 μm). The PCNA+ cell prevalence in the capsules was lower for titanium than for AgP...

STUDY DESIGN An in vitro study examining factors produced by human mesenchymal stem cells on spine implant materials. OBJECTIVE The aim of this study was to examine whether the inflammatory microenvironment generated by cells on titanium-aluminum-vanadium (Ti-alloy, TiAlV) surfaces is affected by surface microtexture and whether it differs from that generated on poly-ether-ether-ketone (PEEK)...