Resistive respiratory loading is an established stimulus for the induction of experimental dyspnoea. In comparison to unloaded breathing, resistive loaded breathing alters end-tidal CO2 (P(ET)CO2), which has independent physiological effects (e.g. upon cerebral blood flow). We investigated the subjective effects of resistive loaded breathing with stabilized P(ET)CO2 (isocapnia) during manual co...

CE Email comments/questions to [email protected], fax 800-556-3288, or log on to www.VetLearn.com Carbon dioxide (CO2) is linked to a patient’s perfusion, ventilation, and metabolism. Endtidal carbon dioxide (ETCO2) is the measurement of CO2 in exhaled respiratory gases and serves as an estimate of arterial CO2. ETCO2 is measured by a capnograph in a mainstream or sidestream method. A no...

Several indices of ventilatory heterogeneity can be identified from the expiratory CO2 partial pressure or CO2 elimination versus volume curves. The aims of this study were: 1) to analyse several computerizable indices of volumetric capnography in order to detect ventilatory disturbances; and 2) to establish the relationship between those indices and respiratory system mechanics in subjects wit...

The Mechanics of Breathing and Stabilization of Ventilation in Patients With Unilateral Cerebral Infarction • The mechanics of breathing and responses of the respiratory system to CO2 during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with ce...

Mechanical ventilation is indispensable for the survival of patients with acute lung injury and acute respiratory distress syndrome. However, excessive tidal volumes and inadequate lung recruitment may contribute to mortality by causing ventilator-induced lung injury. This bench-to-bedside review presents the scientific rationale for using adjuncts to mechanical ventilation aimed at optimizing ...

As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 lev...

BACKGROUND Pulmonary abnormalities are found in both chronic heart failure (CHF) and pulmonary arterial hypertension (PAH). The differences of pulmonary function in chronic left heart failure and chronic right heart failure are not fully understood. MATERIAL AND METHODS We evaluated 120 patients with stable CHF (60 with chronic left heart failure and 60 with chronic right heart failure). All ...

Abbreviations: CO2, Carbon dioxide; PaCO2, Arterial partial pressure of carbon dioxide; PtcCO2, Transcutaneous partial pressure of carbon dioxide; PetCO2, End-tidal partial pressure of carbon dioxide; NETS, Newborn Emergency Transport Service (Victoria); NICU, Neonatal Intensive Care Unit; PaO2/PAO2 ratio, alveolar-arterial ratio. ADC-FNN Online First, published on April 29, 2005 as 10.1136/adc...

Introduction Ventilation of ARDS patients with low tidal volume (Vt) is performed in order to minimize ventilation induced lung injury. This strategy, however, may induce hypercapnic acidosis, promote derecruitment and, in some individuals, induce alveolar overdistention despite the use of low Vt. Extracorporeal CO2 removal can help minimizing hypercapnic acidosis and to further reduce Vt (i.e....

This paper describes the development of a computer-controlled system that controls inspired CO2 or end-tidal PCO2 (PETCO2) to follow preprogrammed functions such as step, sinusoid, and pulse, under normoxic, hyperoxic, and hypoxic conditions. The system uses a proportional-integral (PI) controller that was optimized by adjusting the PI parameters so as to minimize the integral-time of absolute ...