the first and second laws of thermodynamics have been employed to evaluate energy and exergetic efficiency of the single effect absorption chiller which is used for air conditioning purpose. the performance analysis has been carried out by developing a computer program in ees and modeling the chiller and its components. to evaluate entropy of the water/lithium bromide solution at any point, an ...

objective: biopure® mtad (dentsply tulsa dental, usa) has been developed as a final irrigant following root canal shaping to remove intracanal smear layer. many of the unique properties of mtad potentially transfer to the conditioning process of tooth roots during periodontal therapy. the aim of this ex vivo study was to evaluate the effect of mtad on the removal of smear layer from root surfac...

Contextual fear conditioning is regulated by the hippocampus, and NR2B, a subunit of the NMDA receptor (NR), is involved in this process. We show that acute stress modulates tissue plasminogen activator (tPA) activity in the hippocampus by inducing expression of its inhibitor, plasminogen activator inhibitor-1. Acute stress increases NR2B expression and ERK1/2 phosphorylation, a classical marke...

Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human periosteum-derived cells, followed by their assembly into microaggregates simultaneously primed with bo...

Purpose of Review The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clinical setting. Regulatory T cells (Tregs) have been shown to improve chimerism induction in experimental animal models. This review summarizes the development of innovative BMT pr...

The rheology of ultrasoft materials like the human brain is highly sensitive to regional and temporal variations and to the type of loading. While recent experiments have shaped our understanding of the time-independent, hyperelastic response of human brain tissue, its time-dependent behavior under various loading conditions remains insufficiently understood. Here we combine cyclic and relaxati...

background: development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. methods: plla/pcl aligned fibrous scaffold was fabricated using electrospinning method. adscs...

objective: evaluating the effect of dentin conditioning with edta on microleakage of composite resin restorations, using two etch and rinse and two self-etch adhesives. materials and methods: one hundred and sixty extracted molars received class v cavity preparations right under the cej and were randomly divided into eight groups of 20, usingfour different adhesive systems. these adhesives incl...

colchicine, a potent neurotoxin derived from plants, has been recently introduced as a degenerative toxin of small pyramidal cells in the cortical area 1 of the hippocampus (ca1). in this study, the effect of the alkaloid in ca1 on the behaviors in the conditioning task was measured. injections of colchicine (1,5 μg/rat, intra-ca1) was performed in the male wistar rats, while the animals were s...

The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered h...