These abstracts are licensed under a Creative Commons Attribution-NonCommercial-No Derivatives 4.0 International License. Go to http://iovs.arvojournals.org/ to access the versions of record. Purpose: Primary open angle glaucoma is frequently associated with loss and dysfunction of trabecular meshwork (TM) cells. The purpose of this study was to determine if restoration of TM cellularity, using...

Purpose Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic mouse model of POAG (Tg-MYOCY437H) by expressing human mutant myocilin (MYOC), a known genetic cause of POAG. The purpose of this study is to examine whether expression of mut...

conclusions in patients with tm, bone widening, trabeculation, paraspinal masses and facial bone deformity were lower than patients with ti, whichcan be related to effectiveness of therapy with blood transfusion irrespective of its adverse effects in tm patients. results all radiologic findings were significantly higher in patients with ti compared to tm (p< 0.05). in patients with ti, only tra...

CONTEXT Circadian rhythms of plasma parathyroid hormone (PTH) show peak values at night, whereas serum calcium levels peak in the evening and display a nadir at night. HYPOTHESES Subclinical hypoparathyroidism (HPT) can be detected by utilizing the knowledge of diurnal variations. Thalassemia major (TM) may provide a model system of subclinical HPT. DESIGN Nocturnal plasma PTH and serum cal...

— Low temperature magnetization and resistivity measurements in the dilute Tm^Y! _JSe system show both Tm 2 + and Tm 3 + like behavior. However, since the results are nearly linear with concentration, they apparently reflect the properties of each thulium site. This paper presents a new approach to the TmSe mixed valence problem [1]. The idea is to build up the rather complex properties of the ...

Inflammation and thrombosis are increasingly recognized as interrelated biologic processes. Endothelial cell expression of thrombomodulin (TM), a key component of the anticoagulant protein C pathway, is potently inhibited by inflammatory cytokines. Because the mechanism underlying this effect is largely unknown, we investigated a potential role for the inflammatory transcription factor nuclear ...

The invariant imbedding T-matrix method (II-TM) is employed to simulate the optical properties of normal biconcave and deformed red blood cells (RBCs). The phase matrix elements of a RBC model computed with the II-TM are compared with their counterparts computed with the discrete-dipole approximation (DDA) method. As expected, the DDA results approach the II-TM results with an increase in the n...

Tm-1, an inhibitor protein of Tomato mosaic virus RNA replication, contains two conserved domains: an uncharacterized domain at its N-terminus and a TIM-barrel-like domain at its C-terminus. The N-terminal domain of Tm-1 has an inhibitory activity and its three-dimensional structure has not been determined. Here, the crystallization and preliminary X-ray diffraction of the N-terminal domain of ...

AIMS Thrombomodulin (TM), via its lectin-like domain (LLD), exhibits anti-inflammatory properties partly by sequestering the pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Since myocardial damage after ischaemia and reperfusion is mediated by inflammation, we evaluated the cardioprotective effects of the LLD of TM. Using an in vivo mouse model of transient ischaemia and in vitro ...

PURPOSE Transforming growth factor (TGF)-beta2 levels are elevated in glaucomatous human aqueous humor. TGFbeta is a cytokine that alters extracellular matrix (ECM) metabolism, and excess ECM has been proposed to increase aqueous outflow resistance in the trabecular meshwork (TM) of glaucomatous eyes. This study was undertaken to investigate effects of TGFbeta2 on secretion of fibronectin and t...