نتایج جستجو برای: tmprss2
تعداد نتایج: 875 فیلتر نتایج به سال:
Recently, fusion of ERG to the androgen-regulated, prostate-specific TMPRSS2 gene has been identified as the most frequent genetic alteration in prostate cancer. At low frequency, TMPRSS2-ETV1 and TMPRSS2-ETV4 fusion genes have been described. In this study, we report two novel ETV4 fusion genes in prostate cancer: KLK2-ETV4 and CANT1-ETV4. Both gene fusions have important unique aspects. KLK2 ...
Type II transmembrane serine protease (TMPRSS2) is expressed at the cell surface with COVID-19 infection. And infection misuse TMPRSS2 to advance their spread, making this potential focuses for intervention in blocker may be appropriate option arrest cellular entry of by deregulating spike priming. Therefore a trial intended watch adequacy aerosolized spraying inhibitors break viral objective c...
results a total number of 43 specimens were studied, from which 9 were obtained from patients with metastatic prostate cancer. the expression of five examined genes had no correlation with psa level and gleason score. the expression of amacr decreased in metastatic prostate cancer (p = 0.02). the expression of other genes showed no difference between metastatic and non-metastatic tumors (p > 0....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters into host cells through the angiotensin-converting enzyme (ACE2) receptor and transmembrane serine protease (TMPRSS2) helps in propagation. Expression of ACE2 gene was found to be higher kidney, testis, heart, thyroid, adipose tissue whereas expression TMPRSS2 highest small intestine, prostate. increases as age increases. Estro...
Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of pati...
BACKGROUND Numerous genetic variants have been confirmed as prostate cancer risk factors. These variants may confer susceptibility to the development of specific molecular alterations during tumor initiation and progression. The TMPRSS2:ERG gene fusion occurs in roughly 50% of prostate cancers. Genetic risk variants may influence the development of this fusion. We sought to determine whether pr...
BACKGROUND Androgens play a crucial role in prostate cancer, hence the androgenic pathway has become an important target of therapeutic intervention. Previously we discovered that gene fusions between the 5'-untranslated region of androgen regulated gene TMPRSS2 and the ETS transcription factor family members were present in a majority of the prostate cancer cases. The resulting aberrant overex...
Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers. Its relevance in castration-resistant prostate cancer (CRPC) remains controversial as ERG is not expressed in some TMPRSS2-ERG androgen-independent xenograft models. However, unlike these models, CRPC patients have an increasing prostate-specific antigen, indicating ac...
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