Endodontic treatment of immature necrotic teeth is a real challenge. Recently, a biologically based treatment strategy, referred to as regeneration, has been introduced. Tissue regeneration requires the presence of stems cells, a scaffold, and growth factors. Endodontic regeneration may improve the prognosis of immature necrotic teeth by re-establishing the functional pulpal tissue and further ...

The conventional method of apexification with calcium hydroxide has certain disadvantages such as very long period of treatment, tooth fracture and an incomplete calcification of the bridge. Mineral trioxide aggregate (MTA) as an apical sealing material has gained importance as an alternative treatment for open apices. We report a case of complete healing of a periapical abscess after placement...

Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biomineralization (Cui et al., 2015). Here we report the nucleotide-free and ATP-bound structures of ...

Human tooth development is a continuous process begin at the sixth weeks in utero and extends to about sixth months after birth for the primary dentition and from sixteenth week in utero to late adolescence for permanent dentition. There is no other organ of the human body which takes so long to attain its ultimate morphology as dentition. Several physiologic growth processes participate in the...

Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology. Until recently, it was thought to only have an inhibitory role of physiological and e...

A male patient presented with an extraordinarily large calcifying epithelial odontogenic tumor (CEOT or Pindborg-tumor) that affected the maxilla. The disease became evident due to alterations in the facial aspect, in particular of the perioral region, caused by the expanding tumor. CEOT is characterised by the slowly growing mass of part of the jaws. Multilocular or extraosseous manifestations...

Although calcification of the permanent teeth is not radiologically discernible until the first month after birth (GARN, LEWIs, and POLACHECK, J Dent Res 38: 135, 1959) developmental stages of I1, 12, Ml, and often C may be demonstrated in histological sections of jaws well before the 39to 41-week age horizon. It is of interest, therefore, to determine whether intra-uterine development of these...

Despite a body of compelling evidence pertaining to the root canal accessibility of primary teeth, the number of referrals for inaccessibility of primary molars is considerable. The aim of the present study was to evaluate the prevalence of true and false primary molar inaccessibility among subjects who had been referred by general and pediatric dentists. We examined 199 primary molars in 156 p...

Management of fracture dimmature teeth presents a special challenge to dentists. Apexification, Apexogenosis or Regeneration are the only options for conserving such tooth. Traditional apexification with calcium hydroxide is associated with certain difficulties, like longer treatment time, risk of tooth fracture and incomplete calcification of apical bridge. Treatment outcome of regenerations a...

objective(s): vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. mirnas have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. materials and methods: in the current study, we built a vascular calcification rat mode...