The extent of anomalies and developmental aberrations in hemifacial microsomia (HFM) have not yet been fully delineated. Thus, the developmental pattern of the dentition in patients with HFM remains unclear. This study was conducted to investigate the development of the dentition in subjects with varying degrees of HFM and to compare the affected side with the unnaffected side and with data fro...

The most common congenital and developmental anomaly in teeth is the missing of one or more of them. Congenitally missing teeth (CMT) or teeth agenesis mentions failure of tooth formation due to disturbances during the early stages of tooth germ development. There are several definitive treatment options for these patients including fixed, removable or implant-supported prostheses. Economic lim...

Objectives The purpose of this study was to present a case of regenerative endodontic procedure. Case The maxillary 1st premolar of a 9-year-old patient was diagnosed as necrotic. Since the tooth was immature, we decided to treat this tooth with regenerative endodontic procedure. After disinfection of the canal, bleeding was induced by lacerating the peri-apical tissues ...

Tooth development is initiated by epithelial-mesenchymal interactions via basement membrane (BM) and growth factors. In the present study, we found that nephronectin (Npnt), a component of the BM, is highly expressed in the developing tooth. Npnt localizes in the BM on the buccal side of the tooth germ and shows an expression pattern opposite that of the dental epithelial stem cell marker Sox2....

BACKGROUND Chronological age, as recorded by registration of birth date, is referred to throughout an individual's life. This information is relevant in medical and dental practice for evaluating developmental progress, for educational purposes, and in legal matters, particularly in the application of criminal law. The absence of birth date information raises particular concerns, and estimates ...

In the Jackman lab we study the molecular signals responsible for the early stages of tooth development. This summer I studied the role of the transcription factor dlx2b on zebrafish tooth development. Zebrafish teeth are a particularly useful means for examining the effects of molecular signals on development. Teeth, unlike many other organs, develop relatively independently of surrounding tis...

The process of tooth eruption is very complex, and many of its factors remain unknown. Although radiographic features can provide clues into the eruptive potential of a tooth, underlying factors that affect tooth development and eruption are not as well defined, ranging from local disturbances to systemic disease. In addition, it is difficult to predict which teeth will require treatment and wh...

To study tooth cycling in polyphyodont animals, we chose to work on alligators. Alligators have teeth in three phases of development at each tooth location. This assembly of three teeth is called a tooth family unit. As part of the study, in order to study tooth cycling in alligators, we wanted to know the configuration of the tooth family unit in every tooth position. From the surface of the m...

The aim of this study was to describe the expression of genes, including ameloblastin (Ambn), amelogenin X chromosome (Amelx), and enamelin (Enam) during early (pre-secretory) tooth development. The expression of these genes has predominantly been studied at post-secretory stages. Deoxyoligonucleotide microarrays were used to study gene expression during development of the murine first molar to...

Zebrafish lost anterior teeth during evolution but retain a posterior pharyngeal dentition that requires retinoic acid (RA) cell-cell signaling for its development. The purposes of this study were to test the sufficiency of RA to induce tooth development and to assess its role in evolution. We found that exposure of embryos to exogenous RA induces a dramatic anterior expansion of the number of ...