OBJECTIVE Tramadol is a synthetic analgesic of opioids which has more flexible mechanisms of action than typical opioids. Since it has been reported in previous study that typical opioids like morphine can affect the bone homeostasis, it is worthwhile to examine the effects of tramadol on tooth movement. In this study we investigated effects of tramadol on orthodontic tooth movement in rats. ...

The dorsal raphe nucleus (DR), contains 60% serotonergic neurons, which appears to be involved in the control of endogenous pain sensation. MK-801, a non-competitive antagonist of N-methyl-D-aspartate receptors, inhibits spinal nociceptive neurons, however, little information is available about the effect of its administration on the DR. To evaluate the distribution of c-Fos and serotonin expre...

Orthodontic tooth movement occurs as a result of resorption and formation of the alveolar bone due to an applied load, but the stimulus responsible for triggering orthodontic tooth movement remains the subject of debate. It has been suggested that the periodontal ligament (PDL) plays a key role. However, the mechanical function of the PDL in orthodontic tooth movement is not well understood as ...

OBJECTIVE To quantify the amount of tooth movement and orthodontically induced root resorption (OIRR) in ovariectomized rats. MATERIALS AND METHODS Five 10-week-old female Wistar rats undergoing ovariectomy (OVX) were investigated as the experimental group, and the other five without ovariectomy served as the control group. Four weeks after ovariectomy, 25-g nickel-titanium closed-coil spring...

Pulpitis, external root resorption, and pain may be experienced during orthodontic movement. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been suggested to control these changes. The purpose of this study was to observe pulp-dentinal reactions, root resorption, tooth pain, and tooth movement after the application of a 4-ounce intrusive orthodontic force to human maxillary first ...

* Senior Lecturer, Department of Orthodontics, Sri Sankara Dental College, Varkala, Trivandrum, Kerala, India ** Senior Lecturer, Department of Periodontics, Sri Sankara Dental College, Varkala, Trivandrum, Kerala, India *** Senior Lecturer, Department of Periodontics, Kannur Dental College, Anjarakandy, Kannur, Kerala, India † Senior Lecturer, Department of Orthodontics, Kannur Dental College,...

Teeth move through alveolar bone, whether through the normal process of tooth eruption or by strains generated by orthodontic appliances. Both eruption and orthodontics accomplish this feat through similar fundamental biological processes, osteoclastogenesis and osteogenesis, but there are differences that make their mechanisms unique. A better appreciation of the molecular and cellular events ...

Runx2/Cbfa1 is essential for osteoblast differentiation and bone formation. Runx2 null mice (Runx2(-/-)) completely lack mineralized tissue and die soon after birth, whereas Runx2 heterozygous knock-out mice (Runx2(+/-)) stay alive but show morphological defects in the skeletal system as observed in cleidocranial dysplasia (CCD) in humans. The aim of this study is to elucidate the role of Runx2...

OBJECTIVES The aim of this research was to investigate the influence of low-power laser on tooth movement in rats. BACKGROUND Tooth movement is closely related to the process of bone remodeling. The biologic result, with the application of a force to the tooth, is bone absorption on the pressure side and neoformation on the traction side of the alveolar bone. The laser photobiomodulation is c...

OBJECTIVE To determine the location of center of resistance and the relationship between height of retraction force on power arm (power-arm length) and movement of anterior teeth (degree of rotation) during sliding mechanics retraction. MATERIALS AND METHODS Three human subjects with maxillary protrusion were selected for this study. Initial tooth displacements of maxillary right central inci...