This study evaluated the potential of poly(iso-butyl cyanoacrylate) (PBCA) nanocapsules dispersed in a biocompatible microemulsion to facilitate the absorption of insulin following intragastric administration to diabetic rats. Insulin-loaded PBCA nanocapsules were prepared in-situ in a biocompatible water-in-oil microemulsion by interfacial polymerisation. The microemulsion consisted of a mixtu...

The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (henceforth referred to as 5F), to enhance its bioavailability and evaluate its hepatotoxicity. Pseudoternary phase diagrams showed that the optimal microemulsion formulation contained 45% water, 10% castor oil as the oil phase, 15% Cremo...

In this paper we investigate the receipt of cadmium sulfide nanoparticles in the microemulsion system stabilized by nonionic surfactants, and the effect of the volume of microemulsion droplets and supersaturation on the size of the particles formed CdS. The photoluminescence spectrum microemulsion system containing nanoparticles of CdS, is shifted to shorter wavelengths of the spectrum and the ...

The partial phase behavior of systems composed of lecithin/isopropyl myristate (IPM)/water or ketorolac tromethamine (KT) solutions (2.5, 5, 10 and 50% w/w) at various lecithin/IPM weight ratios (km) have been investigated by the construction of phase diagrams. A commercially available soybean lecithin (namely, Epikuron 200, phosphatidylcholine purity greater than 95%) was used in this study. P...

The finite-wavelength instability gives rise to a new type of wave in reaction-diffusion systems: packet waves, which propagate only within a wave packet, are found in experiments on the Belousov-Zhabotinsky reaction dispersed in water-in-oil AOT microemulsion (BZ-AOT) as well as in model simulations. Inwardly moving packet waves with negative curvature occur in experiments and in a model of th...

The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain ...

The objective of the present study was to design and develop a microemulsion based transungual drug delivery formulation of ciclopirox olamine using colloidal carrier for treatment of onychomycosis. Capmul PG8 was selected as oil phase due to the high solubility of ciclopirox in it as compared to other oils and Cremophor EL and Transcutol P were used as surfactant and cosurfactant respectively....

BACKGROUND Microemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine. METHODS...