Cloud computing brings opportunities for network forensics tracing Internet criminals in the distributed environment. We may use the new “pay-as-you-go” model of the cloud computing to deploy the on-demand cyber surveillance sentinels and conduct distributed traceback in complicated cyber crime scene investigations. To trace criminals abusing anonymous communication networks such as Tor, law en...

Research on TOR has grown exponentially during the last decade, generating a complex model of the TOR signaling network. Rapamycin treatment provides a simple and straightforward method to inhibit the TOR signaling pathway and to study the influence of TOR on multiple cellular processes. The discovery of two distinct TOR complexes, TORC1 and TORC2, showed that studies using rapamycin targeted o...

The highly conserved Target of Rapamycin (TOR) kinase is a central regulator of cell growth and metabolism in response to nutrient availability. TOR functions in two structurally and functionally distinct complexes, TOR Complex 1 (TORC1) and TOR Complex 2 (TORC2). Through TORC1, TOR negatively regulates autophagy, a conserved process that functions in quality control and cellular homeostasis an...

To the Editor: The traditional causative agent of cholera, Vibrio chol-erae O1, has 2 biotypes, classical and El Tor. The current seventh pandemic that began in 1961 and has spread to much of the world is caused by the El Tor biotype. This biotype has replaced the classical biotype responsible for the previous pandemics. The classical and El Tor biotypes are differentiated by phenotypic tests (...

The Target of Rapamycin (TOR) growth regulatory system is influenced by a number of different inputs, including growth factor signaling, nutrient availability, and cellular energy levels. While the effects of TOR on cell and organismal growth have been well characterized, this pathway also has profound effects on neural development and behavior. Hyperactivation of the TOR pathway by mutations i...

Tor provides anonymity online by routing traffic through encrypted tunnels, called circuits, over paths of anonymizing relays. To enable users to connect to their selected destination servers without waiting for the circuit to be build, the Tor client maintains a few circuits at all times. Nevertheless, Tor is slower to use than directly connecting to the destination server. In this paper, we p...

Tor is the most popular low-latency anonymity network for enhancing ordinary users’ online privacy and resisting censorship. While it has grown in popularity, Tor has a variety of performance problems that result in poor quality of service, a strong disincentive to use the system, and weaker anonymity properties for all users. We observe that one reason why Tor is slow is due to lowbandwidth vo...

Target of Rapamycin (TOR) is a major nutrition and energy sensor that regulates growth and life span in yeast and animals. In plants, growth and life span are intertwined not only with nutrient acquisition from the soil and nutrition generation via photosynthesis but also with their unique modes of development and differentiation. How TOR functions in these processes has not yet been determined...

TOR kinases integrate environmental and nutritional signals to regulate cell growth in eukaryotic organisms. Here, we describe results from a study combining quantitative proteomics and comparative expression analysis in the budding yeast, S. cerevisiae, to gain insights into TOR function and regulation. We profiled protein abundance changes under conditions of TOR inhibition by rapamycin treat...

In Fusarium fujikuroi, the biosynthesis of gibberellins (GAs) and bikaverin is under control of AreA-mediated nitrogen metabolite repression. Thus far, the signaling components acting upstream of AreA and regulating its nuclear translocation are unknown. In Saccharomyces cerevisiae, the target of rapamycin (TOR) proteins, Tor1p and Tor2p, are key players of nutrient-mediated signal transduction...