Toxicological determinations are crucial to coroners' or medical examiners' judgments that drugs are significantly involved in a death. However, differences in laboratory procedures, thoroughness of screening, and limits of detection may result in artifactual differences in the toxicological results and the subsequent interpretations of them. To test this possibility, we conducted a toxicology ...

The recent paper by McRobbie et al. (1) is the first prospective study addressing toxicological exposure directly in e-cigarettes (ECs) users. This study adds key information about harm potential of e-vapour products and gets away from the controversial toxicological findings that have been generated in recent laboratories studies because of experimental protocols that do not mimic realistic co...

Abstract The samples of plant material suspected to contain new psychoactive substances are very often the subject chemical-toxicological analyses. Gas chromatography-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and chromatography-tandem MS were applied with aim identify synthetic cannabinoid, methyl 2-{[1-(cyclohexylmethyl)-1 H -indol-3-yl] formamido}-3-methylbut...

Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major toxicological/risk assessment texts, governmental regulatory dose-response modeling for risk assessment, and non-visibility in major professional toxicological society national meetings. This paper traces the historical evolution of the hormetic dose-res...

Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo São Paulo/SP, Brazil. Clinical and Toxicological Analysis Department, São Paulo University of Pharmaceutical Sciences Sao Paulo/SP, Brazil. Institute of Mathematics and Statistics, São Paulo University São Paulo/ SP, Brazil. Heart Institute (InCor), São Paulo University Medical School, São Paulo/ SP, Brazil...