BACKGROUND New national guidelines recommend more restricted fluid intake and early initiation of total parenteral nutrition (TPN) in very preterm infants. The aim was study the effect of these guidelines on serum sodium and potassium levels and fluid balance in the first three days after birth. METHODS Two cohorts of infants <28 weeks gestational age, born at the Leiden University Medical Ce...

Although standard supportive care for bone marrow transplant (BMT) recipients includes total parenteral nutrition (TPN), it has not been shown that this is the most appropriate method of nutritional support. To determine whether current BMT recipients require TPN during the early recovery period, we conducted a prospective, randomized clinical trial comparing TPN and an individualized enterai f...

The article in this issue by Dimick et al 1 about total parenteral nutrition (TPN) and infections associated with use of central venous catheters addresses a major concern in critical care medicine. In day-to-day practice, certain intervention-related complications are inevitable. As our understanding in general improves, we find many other factors that contribute to complications. Dimick et al...

Enterocyte apoptosis induced by lipid emulsions is a key cause of intestinal atrophy under total parenteral nutrition (TPN) support, and our previous work demonstrated that olive oil lipid emulsion (OOLE) could induce enterocyte apoptosis via CUGBP, Elav-like family member 1 (CELF1)/ apoptosis-inducing factor (AIF) pathway. As TPN-associated complications are partially related to choline defici...

Feeding strategies to care for patients who transition from enteral nutrient deprivation while on total parenteral nutrition (TPN) to enteral feedings generally proceed to full enteral nutrition once the gastrointestinal tract recovers; however, an increasing body of literature suggests that a subgroup of patients may actually develop an increased incidence of adverse events, including death. T...

Let k an algebraically closed field, P the n-dimensional projective space over k and TPn the tangent vector bundle of P . In this paper I prove the following result : for every integer l, for every non-negative integer s, if Zs is the union of s points in sufficiently general position in P, then the restriction map H(P, TPn(l)) → H 0(Zs, TPn(l)|Zs) has maximal rank. This result implies that the...

BACKGROUND Short bowel syndrome (SBS) can lead to intestinal failure and require total or supplemental parenteral nutrition (TPN or PN, respectively). Glucagon-like peptide 2 (GLP-2) is a nutrient-dependent, proglucagon-derived gut hormone that stimulates intestinal adaptation. OBJECTIVE Our objective was to determine whether supplemental enteral nutrients (SEN) modulate the intestinotrophic ...

INTRODUCTION A preliminary one-year review of total parenteral nutrition (TPN) in the adult surgical intensive care unit (SICU) in view of its complications, cost and lack of consistent benefits in the critically ill. MATERIALS AND METHODS All the case records of patients receiving TPN in the SICU starting from first January to end December 1998 were studied. RESULTS Fifty patients received...

BACKGROUND Hyperglycemia is associated with poor clinical outcomes and mortality in several patients. However, studies evaluating hyperglycemia variation in tumor patients receiving total parenteral nutrition (TPN) are scarce. The aim of this study was to assess the relationship between glycemia and tumor kinds with TPN by monitoring glycemic variation in tumor patients. METHODS This retrospe...

OBJECTIVE To evaluate the potential clinical, metabolic, and economic advantages of enteral nutrition over total parenteral nutrition. DESIGN Prospective, randomized clinical trial. SETTING Department of surgery in a university hospital. PATIENTS Two hundred and fifty-seven patients with cancer of the stomach (n = 121), pancreas (n = 110), or esophagus (n = 26) were randomized to receive ...