Responses to KCl and histamine and 45Ca movements were studied in trachea from normal and actively sensitized guinea-pigs. Sensitized tracheas were hyperresponsive and hypersensitive to KCl and histamine. 45Ca uptake experiments show that sensitized tracheal muscle behaves as normal except that the uptake of 45Ca in low concentration (0.03 mM) Ca2+ solution was higher and the number of binding ...

It is well known that histamine produces constriction via H1 receptors and decreases tracheal smooth muscle tone via H2 and H3 receptors. In addition, it has already been reported that 3-methylhistamine and phenylethylamine are competitive antagonists of histamine N-methyl-transferase (HMT), the enzyme responsible for rapid inactivation of histamine. Our results suggest the possibility that 3me...

Helli, Peter B., Evi Pertens, and Luke J. Janssen. Cyclopiazonic acid activates a Ca -permeable, nonselective cation conductance in porcine and bovine tracheal smooth muscle. J Appl Physiol 99: 1759–1768, 2005. First published July 14, 2005; doi:10.1152/japplphysiol.00242.2005.—Capacitative Ca entry has been examined in several tissues and, in some, appears to be mediated by nonselective cation...

Background The soluble guanylyl cyclase (sGC) is expressed in airway smooth muscle, and agents that stimulate sGC activity cause airway smooth muscle relaxation and bronchodilation. BAY 41-2272 is a potent nitric oxide (NO)-independent sGC stimulator, but little is known about its effects in airway smooth muscle. Therefore, this study aimed to investigate the mechanisms underlying the relaxatio...

BACKGROUND The use of beta-blockers is limited by adverse effects such as bronchospasm in asthmatics. Third generation beta-blockers such as celiprolol may show better respiratory tolerability because they lack beta-blocker induced broncho-constriction. METHOD Effect of celiprolol on the histamine induced contraction of tracheal muscle strips prepared from ovalbumin-sensitised guinea pigs was...

The diverse vocal performances of oscine songbirds are produced by the independent but coordinated patterns of activity in muscles controlling separate sound generators on the left and right sides of their duplex vocal organ, the syrinx. Species with different song styles use the two sides of their syrinx in different ways to produce their species-typical songs. Understanding how a vocal mimic ...

objective(s) the aims of present study were to elucidate the effect of nahs as a h2s donor on precontracted rat trachea smooth muscle, role of epithelium and nitric oxide in this action. materials and methods tracheal rings from male adult wistar rats were isolated and mounted in an organ bath containing krebs–henseleit solution under 1.5 g resting tension and contractions were recorded isometr...

BACKGROUND The Entropy Module anaesthesia monitor displays two spectral entropy-based indices, response entropy (RE) and state entropy (SE). The difference between RE and SE (RE-SE), which mainly reflects electromyography activation, is thought to indicate the adequacy of antinociception. Little is known, however, about the effects of neuromuscular blocking agents on the RE-SE. We investigated ...

Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.Materials and Methods: Tracheal smooth muscle were contracted by 10 μM methacholin...