In trachoma the interaction between chronic chlamydial and acute bacterial conjuntivitis has been suggested as important in determining the severity of disease and, therefore, blindness. We investigated the effect of acute conjunctival infection with each of three common human pathogens, Haemophilus influenzae, Haemophilus aegyptius , and Streptococcus pneumoniae, in a model of trachoma establi...

Trachoma is a leading cause of preventable blindness in the world. The disease is hyperendemic in rural Egypt, where more than 75% of children show signs of having had at least one episode of infectious trachoma during the first year of life. Earlier anthropological and epidemiological observations suggested that trachoma prevalence would decrease if children had their faces washed with soap an...

We aimed to investigate prevalence of potential risk factors, and associations between risk factors and active trachoma in southern Sudan. Surveys were undertaken in ten sites and children aged 1-9 years examined for trachoma. Risk factors were assessed through interviews and observations. Using ordinal logistic regression, associations between severity of active trachoma and risk factors were ...

With less than four years to reach the elimination target for trachoma, we need to tackle this preventable disease head-on. Through the powerful unity of the Alliance for GET2020, there is global commitment to eliminating a disease that has existed for thousands of years. According to data released in April, around 200 million people are at risk of trachoma, 1.2 million people are blind and 3.6...

BACKGROUND In Ethiopia, the prevalence of blindness has been estimated to be 1.5%. According to a survey done in collaboration with WHO in 1981, the leading cause of blindness in Ethiopia was trachoma (42%) followed by cataract (29%). The problem is mainly seen in the rural areas of the country. OBJECTIVE To determine the prevalence and associated risk factors of trachoma in a rural locality ...

BACKGROUND Trachoma is the leading cause of preventable blindness worldwide. It is common in areas where the people are socio-economically deprived. The aim of this study was to assess active trachoma and associated risk factors among children 1-9 years in East Gojjam. METHODS Community-based cross-sectional study was conducted in Baso Liben District from February to April 2012. A two-stage r...

The 1990s was an exciting period for those of us in global health committed to seeing the end of blindness from trachoma. The “SAFE strategy” (surgery for trichiasis, antibiotics, facial cleanliness, and environmental improvement) for trachoma control was developed and endorsed by the World Health Organization; the efficacy of single-dose oral azithromycin against active trachoma was demonstrat...

BACKGROUND Trachoma is the leading infectious cause of blindness in the world. It is commonly found in cultural groups with poor hygiene. Trachoma control includes Surgery, Antibiotics, Facial cleanliness and Environmental Improvement (SAFE). Potentially blinding and active trachoma are monitored using trachomatous trichiasis (TT) in adults and trachoma inflammation-follicular (TF) in children ...

BACKGROUND Trachoma is the leading infectious cause of blindness due to conjunctival infection with Chlamydia trachomatis. The presence of active trachoma and evidence of infection are poorly correlated and a strong immunologically-mediated inflammatory response means that clinical signs last much longer than infection. This population-based study in five Aboriginal communities endemic for trac...

The TRIC-Taiwan-1-1958 strain of elementary body virus isolated from a trachoma patient on Taiwan has been proven capable of reproducing trachoma by experimental inoculation of six human volunteers. Virus material derived from the seventh passage in embryonated hen eggs caused the clinical picture of trachoma in every inoculation, even at the dilution of 10(-4) of infected yolk sacs (approximat...