We describe a 1.2 A X-ray structure of a double-stranded B-DNA dodecamer (the Dickerson Dodecamer, DDD, [d(CGCGAATTCGCG)]2) associated with a cytotoxic platinum(II) complex, [{trans-Pt(NH3)2(NH2(CH2)6(NH3+)}2-mu-{trans-Pt(NH3)2(NH2(CH2)6NH2)2}] (TriplatinNC). TriplatinNC is a multifunctional DNA ligand, with three cationic Pt(II) centers, and directional hydrogen bonding functionalities, linked...

The first base-stabilized iodoborylene platinum complex was prepared through the addition of 4-picoline (4-Pic) to a suspension of an iodo-bridged binuclear iodoboryl complex. An X-ray structure determination of the title compound has characterized the molecular structure as cis-[Pt{BI(4Pic)}I2(PCy3)]. The bond lengths lie in the expected range for neutral, base-stabilized borylene complexes. T...

The synthesis and photophysical study of a perylene diimide (PDI) functionalised with platinum acetylide units of the type, trans{-C≡C-Pt(PBu3)2-C≡C-Ph} and comparison with a phenylacetylide substituted model compound are reported. The model compound demonstrates typical perylene absorption and photoluminescence spectra characteristic of singlet excited state formation and decay. The Pt-substit...

with P(OEt)3 and PPh(OEt)2 Phosphite Ligands G. ALBERTIN, S. ATONIUTTI, C. BUSATO, J. CASTRO and S. GARCIA-FONTÁN, Dalton Trans., 2005, (15), 2641–2649 [PtH{P(OEt)3}4]BF4 was obtained by the reaction of Pt{P(OEt)3}4 with HBF4·Et2O at –80oC. Protonating Pt{PPh(OEt)2}4 gave [PtH{PPh(OEt)2}4]BF4 or [PtH{PPh(OEt)2}3]Y (Y = BF4, CF3SO3, Cl). Complexes PtHClP2 (P = P(OEt)3, PPh(OEt)2) were obtained f...

GRATZEL and R. VÖLKL, Metall. Mater. Trans., 2005, 36A, 681–689 Pt-base alloys (1) with various contents of Al, Cr and Ni were arc melted. Solution heat treatments at 1450oC followed by water quenching gave single phase alloys. Ageing at 1000oC caused the precipitation of L12 ordered particles. (1), comprising (in at.%): 11 Al; 3 Cr; 6 Ni and balance Pt, had cuboidal precipitates with edge leng...

The title compound, [FePt(C12H10P)(C13H13Si)(C18H15P)2(CO)3]·0.5CH2Cl2, represents an example of a phosphido-bridged heterobimetallic silyl complex; these are inter-esting precursors for the coordination and activation of small unsaturated organic mol-ecules. The μ2-PPh2 ligand spans the iron and platinum atoms, which are connected via a metal-metal bond of 2.7738 (4) Å. In contrast to most oth...

Two rabbits were immunized with native DNA modified in vitro by cis-dichlorodiammineplatinum(II) (cis-Pt). The interactions between the antiserum and several natural and synthetic nucleic acids were studied primarily by radioimmunoassays. Native DNA's modified by platinum compounds with labile groups in the cis position are recognized by the antiserum. No cross-reaction is found with native DNA...

1R,2R-Diaminocyclohexane(trans-diacetato)(dichloro)-platinum(IV) (DACH-acetato-Pt) is a novel platinum-based agent that is highly effective against cisplatin-resistant ovarian tumor cells. To probe its cellular mechanism, the effects of DACH-acetato-Pt (0-6.4 microM) on cell cycle checkpoints were examined using the ovarian cancer A2780 cell line as the model system. We found that DACH-acetato-...