Infection is a major cause of mortality and morbidity after thoracic organ transplantation. The microbiological aetiology of the infections is broad necessitating accurate diagnostic evaluation. The aim of the present study was to evaluate the infectious complications after lung and heart transplantation, with a special emphasis on the usefulness of bronchoscopy and the demonstration of cytomeg...

OBJECTIVES The Japanese Liver Transplantation Society is a cooperative research consortium, established in 1980 to characterize and follow trends in patient and graft survival in all liver transplants in Japan. This study evaluated the effect of graft size matching on survival in pediatric recipients of living donor liver transplant. MATERIALS AND METHODS Between November 1989 and December 20...

The immunonutrients arginine and omega-3 fatty acids decrease adverse outcomes after solid organ transplant in humans and experimental animals. Kidney transplant recipients who received daily supplements with arginine (9 g) and canola oil (30 mL) had significantly lower frequencies of complications between 30 days to 3 years than transplant recipients who did not receive supplements. In another...

Background Human Cytomegalovirus (HCMV) is one of the most common infectious complications in renal transplant recipients. Extensive genetic polymorphisms in envelope glycoproteins of HCMV have been demonstrated among clinical HCMV isolates. Some previous studies have proposed the potential linkage between HCMV gN genotype to the frequency of symptomatic infection and clinical outcome in renal ...

BACKGROUND We examined whether registered and unregistered donors' perceptions about transplant recipients' previous behavior (e.g., substance use) and responsibility for illness differed based on their deceased organ donor registration decisions. METHODS Students and community members from Queensland, Australia, were surveyed about their perceptions of transplant recipients. RESULTS Respon...

BACKGROUND Data on the risk factors and clinical course of hungry bone syndrome are lacking in dialysis and renal transplant patients who undergo parathyroidectomy. In this study, we aimed to assess the risks and clinical course of hungry bone syndrome and calcium repletion after parathyroidectomy in dialysis and renal transplant patients. METHODS We performed a retrospective review of parath...

OBJECTIVES Therapeutic monitoring of sirolimus and everolimus is necessary in order to minimize adverse side-effects and to ensure effective immunosuppression. A sirolimus-dosing model using the concentration/dose ratio has been previously proposed for kidney transplant patients, and the aim of our study was the evaluation of this single model for the prediction of trough sirolimus and everolim...

BACKGROUND Osmotic and neural factors stimulate neuroendocrine activity during exercise. In contrast to excitatory mechanisms, afferent information from cardiac mechanoreceptors inhibits integrative centers in the hypothalamus and medula oblongata, which serves to buffer neuroendocrine activity. Orthotopic cardiac transplantation results in the loss of afferent information from cardiac mechanor...