Telomerase is a ribonucleoprotein with the function of a DNA polymerase, in which a segment of the RNA component operates as an internal template. It adds hexameric (TTAGGG) repeats to the telomeric ends of the chromosomes, thus compensating for the continued erosion of the telomeres that occurs in its absence (3,7). Reactivation of telomerase might be a necessary event for the sustained growth...

abstract during growing seasons of years 2006 & 2007, a faunistic survey on syrphidae family(diptera) in agroecosystems of neyshabor region, khorasan-e-razavi province was carried out. in this study, 3 collection methods: yellow water trap, malaise trap and sweeping net were applied. the results showed a large difference between different collection methods. specimens of 14 species collected by...

fruit fly, ceratitis capitata (diptera:tephritidae), worldwide. to determine the best combination of trap and attractant for mass trapping of mediterranean fruit fly, a field experiment was conducted in a randomized complete block design (rcbd) with 6 treatments in 3 replications in a pomegranate orchard in shiraz (iran) in 2009. treatments included: 1-jackson trap baited with trimedlure, 2- mc...

The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described. Four hybrid acridine-HSP90 inhibitor conjugates were prepared using a click-chemistry approach, and subsequently shown to display comparable results to the established telomerase inhibitor BRACO-19 in the TRAP-LIG telomerase assay. The conjugates als...

The reaction of the hydroxyl radical, generated by a Fenton system, with pyrimidine deoxyribonucleotides was investigated by using the e.s.r. technique of spin trapping. The spin trap t-nitrosobutane was employed to trap secondary radicals formed by the reaction of the hydroxyl radical with these nucleotides. The results presented here show that hydroxyl-radical attack on thymidine, 2-deoxycyti...

To elucidate the direct role and mechanism of FGFR1 signaling in the differentiation and activation of osteoclasts, we conditionally inactivated FGFR1 in bone marrow monocytes and mature osteoclasts of mice. Mice deficient in FGFR1 (Fgfr1(-/-)) exhibited misregulated bone remodeling with reduced osteoclast number and impaired osteoclast function. In vitro assay demonstrated that the number of t...

The ends of human chromosomes consist of several kilobases of simple telomeric repeats (TTAGGG)n (1). Telomeres are important for maintaining chromosome structure by protecting the chromosomes from DNA degradation, end-to-end fusions, rearrangements, and chromosome loss. Because DNA polymerases synthesize DNA in the 59 to 39 direction and require an RNA primer for initiation, telomeric DNA may ...

This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) low-traffic (LT) areas Malaysia. Respondents’ background information personal traffic sources were obtained from questionnaires distributed randomly selected children. Real-time monitoring instruments used for 6-h measuremen...

Objective(s):Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. Telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. A relation between telomerase activity and resistance to apoptosis has been established. T...