In the past 2 decades, discovery of a new class small RNAs, known as tRNA-derived fragments (tRFs), shed light on layer regulation implicated in many biological processes. tRFs originate from mature tRNAs and are classified according to tRNA regions that they derive from, namely 3′tRF, 5′tRF, tRF-halves. Additionally, another tRF subgroup deriving precursors has been reported, 3′U tRFs. length ...

This paper describes aspects of a project, named APSI (Advanced Planning and Scheduling Initiative), aiming at creating a general, flexible and reusable software architecture to address planning problems in space missions. It introduces our recent work that realized a general software framework for supporting development of planning and scheduling applications for space. The framework which is ...

Total protein (TP), albumin (Alb), transferrin (TRF), retinol-binding protein (RPB), N-acetyl-beta-glucosaminidase (NAG), alanine aminopeptidase (AAP), gamma-glutamyltransferase (GGT), and creatinine (Cr) were measured in random (untimed) urine samples from 29 nonpregnant women and from pregnant subjects (11 in the first trimester, 34 in the second, and 37 in the third). The excretion of TP, Al...

MOTIVATION It has been known that mature transfer RNAs (tRNAs) that are encoded in the nuclear genome give rise to short molecules, collectively known as tRNA fragments or tRFs. Recently, we reported that, in healthy individuals and in patients, tRFs are constitutive, arise from mitochondrial as well as from nuclear tRNAs, and have composition and abundances that depend on a person's sex, popul...

Ultrasound (US) image restoration from radio frequency (RF) signals is generally addressed by deconvolution techniques mitigating the effect of system point spread function (PSF). Most existing methods estimate tissue reflectivity (TRF) so-called fundamental US images, based on an model assuming linear wave propagation. However, several human tissues or with contrast agents have a nonlinear beh...

UNLABELLED The present study employed mass sequencing of small RNA libraries to identify the repertoire of small noncoding RNAs expressed in normal CD4(+) T cells compared to cells transformed with human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell leukemia/lymphoma (ATLL). The results revealed distinct patterns of microRNA expression in HTLV-1-infected CD4(+) T-ce...

Glucocorticosteroids (GCS) added to otherwise unstimulated cultures of human peripheral blood mononuclear cells (PBMC) induce the synthesis and secretion of all classes of immunoglobulin. The magnitude of this response is similar to that seen with other polyclonal B cell activators such as pokeweed mitogen (PWM), and like that of PWM, the steroid effect is dependent on both T cells and monocyte...

Background: Idiopathic pulmonary arterial hypertension (PAH) is a potentially fatal vascular disease with an extremely poor natural course. The limitations of current treatment and the unclear etiology pathogenesis idiopathic PAH require new targets avenues exploration involved in PAH. tRNA-derived small RNAs (tsRNAs), type non-coding RNAs, have significant part progress diverse diseases. Howev...

Far-red fluorescent proteins are critical for in vivo imaging applications, but the relative importance of structure versus dynamics in generating large Stokes-shifted emission is unclear. The unusually red-shifted emission of TagRFP675, a derivative of mKate, has been attributed to the multiple hydrogen bonds with the chromophore N-acylimine carbonyl. We characterized TagRFP675 and point mutan...

The thermogenic response to food (TRF) and substrate oxidation were studied in 12 endurance-trained and 13 untrained female subjects. Energy expenditure and substrate oxidation were calculated by indirect calorimetry before and for 6 h after an oral test meal and after the same meal given intragastrically on a separate occasion. The TRF was calculated after the oral meal, the obligatory compone...