Services such as Wikipedia, Flickr, Technorati, Yahoo!, YouTube, del.icio.us appear in many web applications, employ the folksonomy as their social tagging mechanism, where users assign tags to resources and share it with each other within their community. As the number of the folksonomy-based systems is increased, some proper data mining approaches to folksonomies are necessary to better under...

Disentangling the mechanisms underlying the social network evolution is one of social science’s unsolved puzzles. Preferential attachment is a powerful mechanism explaining social network dynamics, yet not able to explain all scaling-laws in social networks. Recent advances in understanding social network dynamics demonstrate that several scaling-laws in social networks follow as natural conseq...

Aberrant activation of β-catenin/Tcf-4 signaling has been implicated in human carcinogenesis, including colorectal cancer. In this study, we compared the effects of Tcf-4 knockdown with β-catenin knockdown on cell proliferation, apoptosis, and chemosensitivity in SW480 and HCT116 colon cancer cells using adenoviral vector-mediated short hairpin RNA (shRNA). Our results show that, compared to β-...

Triadic distance models can be used to analyse proximity data defined on triples of objects. Three-way symmetry is a common assumption for triadic distance models. In the present study three-way symmetry is not assumed. Triadic distance models are presented for the analysis of asymmetric three-way proximity data that result in a simultaneous representation of symmetry and asymmetry in a low-dim...

the effect of test on teachers, students, and their classroom behaviors has ever been amenable to scholarly studies. to explore such an effect, 20 professors offering ma tefl preparation courses and 30 candidates received plsp and apals inventories. paired-sample t-tests revealed significant differences. however, the respective componential multivariate anova revealed non-significant and signif...

A major outcome of the canonical Wnt/beta-catenin-signalling pathway is the transcriptional activation of a specific set of target genes. A typical feature of the transcriptional response induced by Wnt signalling is the involvement of Tcf/Lef factors that function in the nucleus as the principal mediators of signalling. Vertebrate Tcf/Lef proteins perform two well-characterized functions: in a...

T-cell factor (TCF)-1 protein forms the transcriptional complex with beta-catenin and regulates the expression of diverse target genes during early development and carcinogenesis. We have selected previously an RNA aptamer that binds to the DNA-binding domain of TCF-1 and have shown that it interfered with binding of TCF-1 to its specific DNA recognition sequences in vitro. As an approach to mo...

The ester functionality is commonly seen in the areas of chemical biology and medicinal chemistry for design cell-permeable active molecules. Ester-based pro-drug/pro-sensor strategies are employed to mask polar functional groups (i. e. carboxylic acids) improve overall cell permeability these However, their use as reactive units sensing applications, including bacterial detection, has not been...

In this article, we provide a framework for analyzing and interpreting sources that inform a literature review or, as it is more aptly called, a research synthesis. Specifically, using Leech and Onwuegbuzie’s (2007, 2008) frameworks, we delineate how the following four major source types inform research syntheses: talk, observations, drawings/photographs/videos, and documents. We identify 17 qu...