Distribution of protein kinase C in the CNS of rat is presented based on immunohistochemical analysis with monoclonal antibodies against this protein kinase. Protein kinase C-like immunoreactivity was discretely localized and associated with neurons. Most, if not all, glial cells were not significantly stained. The greatest density of the immunoreactive material was seen in the following region...

We have used the retrograde transport of Fast blue (FB) to study the origins of supraspinal projections to the lumbar and cervical spinal cord at different stages of development in the Brazilian, short-tailed opossum, Monodelphis domestica. Monodelphis was chosen for study because its young are born in a very immature state, 14-15 days after copulation, making it possible to manipulate its nerv...

brainstem, there are 3 separate and complete somatotopic barrelette representations, the principal sensory nucleus, the spinal trigeminal subnucleus interpolaris, and the spinal trigeminal subnucleus caudalis. Broadly, the principal trigeminal sensory nucleus is vital to the sense of discriminative touch, whereas the subnucleus caudalis is important for pain sensation, and the subnucleus interp...

Objective.—To explore whether pharmacological stimulation of the 5-hydroxytryptamine7 (5-HT7) receptor modulates Fos-like immunoreactivity in the trigeminal nucleus caudalis of rats. Background.—The serotonin 5-HT7 receptor was proposed to be involved in migraine pathogenesis and evidence suggests it plays a role in peripheral nociception and hyperalgesia through an action on sensory afferent n...

Gastrin-releasing peptide (GRP) has recently been identified as an itch-signaling molecule in the primary afferents and spinal cord of rodents. However, little information exists on the expression and localization of GRP in the trigeminal somatosensory system other than in rats. We examined the generality of the trigeminal GRP system in mammals using two distinct species, suncus as a model of s...

BACKGROUND The dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following partial ligation of infraorbital nerve (pIONL), a model for trigeminal neuropathic pain. Mechanical allodynia was enhanced in KOR gene deleted mice (KOR-/-) compared to wild type mice. Using bromodeoxyuridine (BrdU) ...

Proprioception from masticatory apparatus and periodontal ligaments comes through the trigeminal mesencephalic nucleus (Vmes). We evaluated effects of tooth loss on neurodegeneration Vmes motor (Vmo). Bilateral maxillary molars 2-month-old C57BL/6J mice were extracted under anesthesia. Neural projections to periodontium confirmed by injecting Fluoro-Gold (FG) retrogradely into extraction socket...

PURPOSE To report a rare case of painful trigeminal neuropathy after lateral medullary infarct and probe its underlying pathogenesis on the basis of neuroimaging and electrophysiological study. CASE REPORT A 45-year-old man presented acute onset of unsteady gait followed by paroxysmal and electric shock-like headache in the distribution of ophthalmic branch of left trigeminal nerve in 2 days....