The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions. The crystal structure of TRIM21 PRYSPRY in complex with its target Ig...

We study the distributed control of heating, ventilation, and air conditioning systems in buildings. We present and compare two control design techniques. In the first part, a one-step distributed model predictive controller (DMPC) is introduced. We compute the explicit state-feedback solution and show how to implement it on existing networked buildings control platforms. In the second part, we...

The male-sterile ms2 mutant has been known for 40 years and has become extremely important in the commercial production of wheat. However, the gene responsible for this phenotype has remained unknown. Here we report the map-based cloning of the Ms2 gene. The Ms2 locus is remarkable in several ways that have implications in basic biology. Beyond having no functional annotation, barely detectable...

The tripartite motif (TRIM) of nuclear factor 7 is required for its association with transcription units" (2007). Peter Jones Lab. 22.

In this paper, we introduce a design criterion for motion primitives of a helicopter when engine failure occurs. A flight plan followed by such a helicopter after it has established autorotation consists of concatenation of such well-defined motion primitives. A library of primitives act as an useful finite action space for a motion planner to search over. Subject to the constrained flight dyna...

The new Lcica RM 2165 automatic, heavy-duty microtome has an advanced step motor that permits an exact specimen feed and reproducible sectioning results. Features include 70 mm vertical stroke length, unique step trim function, and programmable specimen retraction. Technical features include a handwheel rocking sectioning mode; the motorized specimen feed can be linked to change the handwheel t...

A method for trimming surfaces generated as solutions to Partial Differential Equations (PDEs) is presented. The work we present here utilises the 2D parameter space on which the trim curves are defined whose projection on the parametrically represented PDE surface is then trimmed out. To do this we define the trim curves to be a set of boundary conditions which enable us to solve a low order e...

Living cells are realized by complex gene expression programs that are moderated by regulatory proteins called transcription factors (TFs). The TFs control the differential expression of target genes in the context of transcriptional regulatory networks (TRNs), either individually or in groups. Deciphering the mechanisms of how the TFs control the differential expression of a target gene in a T...

Primate tripartite motif 5alpha (TRIM5alpha) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIM5 is located in a paralogous cluster that includes TRIM6, TRIM34, and TRIM22. Although TRIM6 and TRIM34 orthologs are found in other mammals, TRIM5 has to date been identified only in primates. Cow cells exhibit early blocks to infection by several retroviruses. We ident...

Estimating the line origin of chromosomal sections from marker genotypes is a vital step in quantitative trait loci analyses of outbred line crosses. The original, and most commonly used, algorithm can only handle moderate numbers of partially informative markers. The advent of high-density genotyping with SNP chips motivates a new method because the generic sets of markers on SNP chips typical...