OBJECTIVE To study the relationship between toxicity and the exposure to nelfinavir and saquinavir as part of a quadruple drug regimen. DESIGN The ADAM study is a randomized study to investigate the feasibility of induction-maintenance therapy in HIV-1 infection. METHODS HIV-1-infected patients with no prior use of antiretroviral treatment started induction therapy consisting of stavudine +...

Diisobutylaluminium hydride (DIBAL-H) mediated reductive removal of benzyl groups was investigated for perbenzylated alpha-, beta- and gamma-cyclodextrins using DIBAL-H in hexane as the reagent. It was found that under the new conditions, the debenzylation can be better controlled to provide sequentially tri- and tetra-debenzylated products in moderate yields and in a regioselective manner. In ...

The upper chromatic number χ(H) of a set system H is the maximum number of colours that can be assigned to the elements of the underlying set of H in such a way that each H ∈ H contains a monochromatic pair of elements. We prove that a Steiner Triple System of order v ≤ 2 − 1 has an upper chromatic number which is at most k. This bound is the best possible, and the extremal configurations attai...

background: helicobacter pylori (h.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. this study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. methods: in this open-label randomized clinical trial study 120 patients who...

Let n be an integer. A set ofm positive integers is called a D(n)-m-tuple if the product of any two of them increased by n is a perfect square. In this paper, we consider extensions of some parametric families of D(16)-triples. We prove that if {k − 4,k + 4,4k,d}, for k ≥ 5, is a D(16)-quadruple, then d = k3 − 4k. Furthermore, if {k− 4,4k,9k− 12}, for k > 5, is a D(16)-quadruple, then d = 9k3− ...

BACKGROUND As standard triple therapies of achieve unsatisfactory eradication of Helicobacter pylori, several alternative regimens have been proposed. OBJECTIVES To systematically evaluate whether sequential treatment eradicates H. pylori infection better than standard triple therapies and compare the risk of adverse events with these two regimens. METHODS We searched electronic databases u...

Triple antiplatelet therapy has been known to be superior to the conventional dual regimen for preventing stent thrombosis after coronary stenting, and the addition of oral anticoagulation to antiplatelet therapy is also considered an option. However, the risks and benefits of a triple antiplatelet regimen plus additional oral anticoagulation must be taken into account. Here, we report a case o...