نتایج جستجو برای: tryptophan synthase

تعداد نتایج: 99594  

2012
Munehiro Uda Hiroaki Kawasaki Ayako Shigenaga Takeshi Baba Fumiyuki Yamakura

Nitration of tryptophan residues is a novel post-translational modification. In the present study, we examined whether NO2Trp (nitrotryptophan)-containing proteins are produced in the hippocampus and cerebellum of the adult rat under physiological conditions in vivo. Using Western blot analysis with anti-6-NO2Trp-specific antibody, we found many similar immunoreactive spots in the protein extra...

2012
Elizabeth C. Nowak Victor C. de Vries Anna Wasiuk Cory Ahonen Kathryn A. Bennett Isabelle Le Mercier Dae-Gon Ha Randolph J. Noelle

Nutrient deprivation based on the loss of essential amino acids by catabolic enzymes in the microenvironment is a critical means to control inflammatory responses and immune tolerance. Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion of tryptophan to serotonin and exhausts tryptophan, is a potent regulator of immunity. In models o...

Journal: :International archives of allergy and immunology 2016
Johanna M Gostner Katrin Becker Heinz Kofler Barbara Strasser Dietmar Fuchs

Allergic diseases such as asthma and rhinitis, as well the early phase of atopic dermatitis, are characterized by a Th2-skewed immune environment. Th2-type cytokines are upregulated in allergic inflammation, whereas there is downregulation of the Th1-type immune response and related cytokines, such as interferon-x03B3; (IFN-x03B3;). The latter is a strong inducer of indoleamine 2,3-dioxygenase-...

Journal: :Microbiology 2005
Inge A Unsöld Shu-Ming Li

A putative dimethylallyltryptophan synthase gene, fgaPT2, was identified in the genome sequence of Aspergillus fumigatus. fgaPT2 was cloned and overexpressed in Saccharomyces cerevisiae. The protein FgaPT2 was purified to near homogeneity and characterized biochemically. This enzyme was found to convert L-tryptophan to 4-dimethylallyltryptophan, a reaction known to be the first step in ergot al...

2017
Qingyang Xu Fang Bai Ning Chen Gang Bai

The implementation of a novel cell recycling technology based on a special disk centrifuge during microbial fermentation process can continuously separate the product and harmful intermediates, while maintaining the cell viability owing to the installed cooling system. Acetate accumulation is an often encountered problem in L-tryptophan fermentation by Escherichia coli. To extend our previous s...

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