The variable number of tandem repeat (VNTR) of thymidylate synthase (TS) gene, mainly 2 repeat (2R) and 3 repeat (3R), is one of the genetic variations that can potentially predict the effectiveness of 5-fluorouracilbased chemotherapy. In this study we identified an additional single nucleotide polymorphism (SNP) in the VNTR of TS, followed by functional and clinical analysis of the SNP. Two-hu...

A large number of mutants that are temperature sensitive (ts) for growth have been isolated from mouse mammary carcinoma FM3A cells by an improved selection method consisting of cell synchronization and short exposures to restrictive temperature. The improved method increased the efficiency of isolating DNA ts mutants, which showed a rapid decrease in DNA-synthesizing ability after temperature ...

PURPOSE Titanium silicate (TS)-1 chemotherapy has been widely used against gastric cancer in Japan. The aim of the present study was to assess the efficacy and hematological safety of TS-1 as treatment for advanced and recurrent gastric cancer. METHODS From September 2006 to February 2011, 51 advanced or recurrent gastric cancers were treated with TS-1. One course of treatment consisted of 40...

We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene at positions C677T and A1298C were associated with lower risk of adult acute lymphocytic leukemia (ALL). In the present study, we have examined whether polymorphisms in other folate-metabolizing genes play a role in ALL susceptibility. Polymorphisms in methionine synthase (MS A2756G), cytoso...

A series of polystyrene hybrid nanocomposites have been fabricated with varying amounts of TiO2 viz., 0, 0.5 and 1 % w/w along with 3% TS by in-situ polymerization method. The influence of surface modified TiO2 nanoparticles on the thermal properties of PS matrix was examined using thermogravimetry and differential scanning calorimetry. Thermal characteristics of the polystyrene/TS/TiO2 hybrid ...

As a current member of ACEN, I am pleased to have an opportunity in this column to profile briefly an upcoming CHSRF-funded study of Canadian nursing leadership. The study is officially entitled “A Profile of the Structure and Impact of Nursing Management in Canadian Hospitals,” and was approved for funding by the Canadian Health Services Research Foundation (Project Identifier: RC10964-06) in ...

Before an outline of the process of diagnosis and differential diagnosis in infectious and/or inflammatory psy-chosyndromes is given, a more general overview onto the approach to organic psychosyndromes seems useful, because in both entities similar principles of causality conclusion are applied. Correlation does not demonstrate causality. Therefore the principles and consensus recommendations,...

Provide a point-by-point response to all reviewer comments, structured as: B author’s response to the reviewer (in a respectful tone); B changes to the paper (whether and where). Provide a marked revision of your paper. In case of rejection: B do not get frustrated and motivate yourself to move on quickly; B improve your paper if possible, based on the reviewers’ comments; and B submit the new ...

An “In house” PCR method was compared with three commercial PCR kits for the detection of Mycoplasma gallisepticum (MG) in cultures grown in a modified Frey broth or agar, in vaccines, as well as in tracheal swabs of SPF chickens infected experimentally. The studied methods showed different specificity (poor specificity of commercial A test) and sensitivity. The “in house” method appeared to be...