Study comprised one thousand suspected individuals (884 females and 116 males) reported for the screening of thyroid disorders of different age and sex from Kangra district of Himachal Pradesh. History, sign and symptoms of individuals were recorded and total triiodothyronine (TT3), thyroxine (TT4) and thyroid stimulating hormone (TSH) levels were estimated by using micro well Enzyme Linked Imm...

Increases in the terrestrial levels of ultraviolet-B (UV-B) radiation (280 to 320 nm) due to diminished stratospheric ozone have prompted an investigation of the protective mechanisms that contribute to UV-B tolerance in plants. In response to UV-B stress, flowering plants produce a variety of UV-absorptive secondary products derived from phenylalanine. Arabidopsis mutants with defects in the s...

Aglycone flavonols are thought to modulate auxin transport in Arabidopsis thaliana via an as yet undefined mechanism. Biochemical studies suggest that flavonoids interact with regulatory proteins rather than directly with the PIN auxin efflux facilitator proteins. Auxin transport is enhanced in the absence of flavonoids (transparent testa4 [tt4]) and reduced in the presence of excess flavonols ...

Background: Thyroid function tests are among the most commonly ordered laboratory tests in the province. In the past, investigations of thyroid disease required more than one test. Sensitive thyroid stimulating hormone (TSH) is the initial test in the diagnosis of hypothyroidism and hyperthyroidism. Free T4 is preferred over total T4 (TT4) measurement to confirm the diagnosis of hypothyroidism ...

Custom TAL effector nucleases (TALENs) are increasingly used as reagents to manipulate genomes in vivo. Here, we used TALENs to modify the genome of the model plant, Arabidopsis thaliana. We engineered seven TALENs targeting five Arabidopsis genes, namely ADH1, TT4, MAPKKK1, DSK2B, and NATA2. In pooled seedlings expressing the TALENs, we observed somatic mutagenesis frequencies ranging from 2-1...

We measured total thyroxin (Tr4), free thyroxin(FT4, total triiodothyronine (TT3), free triiodothyronine (FT3), and thyrotropin (TSH) in serum sampled before and 1, 2, 4, 6, and 8 h after administration of prescribed doses of thyroxin to 12 patients with proven primary hypothyroidism. At 2, 4, and 6 h post-dose, the mean values for 114 and FT4 and also that at 8 h for FT4 significantly (P <0.05...

We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30-50% of the plasma. The concentrations of...

A 25 YO woman presents to the clinic complaining that over the past few months she has difficulty performing many physical tasks due to severe muscle weakness, and frequently feels "hot and sweaty", even when the weather is cool. She also says she can feel her heart pounding all the time and has developed tremors and difficulty swallowing. Physical examination reveals a BP of 180/90, a pulse of...