The purpose of the present study was to develop and assess a novel sustained-release drug delivery system of Bimatoprost (BIM). Chitosan polymeric inserts were prepared using the solvent casting method and characterized by swelling studies, infrared spectroscopy, differential scanning calorimetry, drug content, scanning electron microscopy and in vitro drug release. Biodistribution of 99mTc-BIM...

PURPOSE The purposes of this project were to assess the effect of four different shoe inserts on the path of the center of pressure (COP), to quantify the effect of these inserts on selected knee joint moments during running, and to assess the potential of COP data to predict the effects of inserts/orthotics on knee joint moments. METHODS Kinematics for the lower extremities, resultant ankle ...

To prevent prescription errors caused by information systems, a database to store complete and accurate drug information in a user-friendly format is needed. In previous studies, the primary method for obtaining data stored in a database is to extract drug information from package inserts by employing pattern matching or more sophisticated methods such as text mining. However, it is difficult t...

Alu elements are trans-mobilized by the autonomous non-LTR retroelement, LINE-1 (L1). Alu-induced insertion mutagenesis contributes to about 0.1% human genetic disease and is responsible for the majority of the documented instances of human retroelement insertion-induced disease. Here we introduce a SINE recovery method that provides a complementary approach for comprehensive analysis of the im...

Introduction: Ultra High Molecular Weight Polyethylene (PE) remains the primary bearing surface of choice in total knee replacements (TKR). Traditionally Archard’s Law is used to predict wear rates in hip and knee prostheses. This assumes that the volume of wear between two articulating surfaces is proportional to the applied load and sliding distance. However it has been shown that this is a s...

The article presents the study of political communication on social network “Facebook”. object is motivation using Russian inserts and potential influence effectiveness discourse. Effectiveness related to persuasion, goal addressee in process main concept rhetoric, therefore, a rhetorical discourse analysis was used for research. focus presented research language posts by Lithuanian politicians...

Forming micro-dimples nearer to the cutting edge on rack face of tungsten carbide inserts will positively influence machinability. However, it is challenging machine perfect micro-dimple dimensions by utilizing available machining techniques. Finite element analysis can be an efficient way observe dimple-texture area density, size, and various shapes inserts' This paper numerically analyses imp...

Eighty-one prepubertal beef heifers were used to evaluate effects of used controlled internal drug release (CIDR) insert heating methods on concentrations of progesterone after CIDR insert reinsertion. Heifers were stratified by weight and birth date and then assigned to receive a new CIDR insert (New; n = 10) or 1 of 8 used (7 d prior use) CIDR insert treatments: 1) no processing (Used; n = 10...

The hemolytic, uropathogenic Escherichia coli 536 (O6:K15:H31) contains two inserts in its chromosome (insert I and insert II), both of which carried hly genes, were rather unstable, and were deleted spontaneously with a frequency of 10(-3) to 10(-4). These inserts were not found in the chromosome of two nonhemolytic E. coli strains, whereas the chromosomal sequences adjacent to these inserts a...