The mechanism of streptomycin action in tuberculosis still appears to be an open question. Although from the first suggestion of its use for treating tuberculous man, it was taken for granted that its action was simply that of a tuberculostatic agent in vivo, simulating the action noted in vitro in certain culture tests under definitely established conditions. There were a few enthusiasts who l...

On pr imary isolation from natural sources, bovine tubercle bacilli grow more poorly on ordinary culture media than do human tubercle bacilli. After prolonged incubation or numerous transfers, however, they often give rise to variants which grow more rapidly (1-4). The primary, slow growing cultures have been called "dysgonic" and the var iant rapidly growing strains "eugonic" (S). The experime...

Seibert (1930) found that the tuberculin proteins of the three varieties of tubercle bacillus could be distinguished by the precipitin test. If this method could be adapted for identifying tubercle bacilli, it would be preferable to animal inoculation. The behavior of the tuberculin proteins of acid-fast bacteria in the precipitin test is interesting not only as a possible means of identificati...

The authors present two patients with subarachnoid hemorrhage caused by ruptured intracranial saccular aneurysms of the persistent primitive hypoglossal artery. A standard unilateral suboccipital approach in one patient resulted in incomplete neck clipping since the operative field was restricted by a protruding jugular tubercle. Successful aneurysmal neck clipping was achieved in the second pa...

In the previous report (Minami, 1957), the bactericidal action of oleic acid on tubercle bacilli was studied, and it was concluded that some particular portion of the cell's surface structure was concerned with this action. In the present paper, the electron microscopic studies were carried out to look for a morphological base for the bactericidal action of oleic and other homologous fatty acid...

Tubercle bacilli die much more rapidly under anaerobic than under aerobic conditions. Anaerobically, the rate of death is accelerated by increased CO(2) pressure, and when certain metabolites (lactate for example) are present in the medium. Death of the bacilli under certain conditions of anaerobiosis is accompanied by loss of ability to take the acid-fast stain and by progressive cellular disi...

We have shown that splenic lymphocytes from mice immunized with viable attenuated mycobacterial cells (H37Ra) or ribonucleic acid prepared from these cells will bring about inhibition of multiplication of virulent tubercle bacilli (H37Rv) within normal mouse peritoneal macrophages in tissue culture. Apparently these lymphocytes, when stimulated with viable virulent tubercle bacilli, elaborate a...

The teguments of males from 5 populations of S. mattheei, of which 3 were sympatric and 2 allopatric with S. haematobium, were studied by means of scanning electron microscopy (SEM). A certain percentage of the males of each sympatric population bore tubercle spines while the allopatric populations were spineless. It is postulated that the presence of tubercle spines is a characteristic inherit...

Over the past decade, the genetics of external genital development have begun to be understood. Male and female external genitalia develop from the genital tubercle. The early tubercle has a superficial resemblance to the limb bud, but an important distinction is that the limb consists of only mesoderm and ectoderm, whereas the genital tubercle also has an endodermal component, the urethral epi...