of the ulcer, its history, and symptoms, are given. The difficulty in effecting a diagnosis between this ulcer and a solitary tuberculous ulcer is adequately recognised. Visual aspects do not enable the distinction to be made; the course of the cases must be watched lor long periods, and evidence of the presence or absence of other possible tubercular lesions in the genitourinary organs careful...

Central nervous system (CNS) tuberculosis commonly manifests as tubercular meningitis CNS tuberculomas are more common intracranially and less frequently involve the spinal cord. We report an unusual case of CNS tuberculosis presented with predominant features of tubercular meningitis with concurrent intra-cranial and intra-medullary tuberculomas in any evidence of pulmonary disease. Most notic...

Tubercular spondylitis is a common extrapulmonary manifestation of tuberculosis. It accounts for 50% skeletal tuberculosis.[1] In most cases, associated symptoms are not so unique as to immediately indicate the proper diagnosis. Differentiating spinal tuberculosis from pyogenic osteomyelitis often very difficult, and metastatic lesion systemic malignancy other major entity which must be differe...

INTRODUCTION Osteonecrosis (avascular necrosis) is known to be caused by high-dose corticosteroid therapy, alcoholism and rarely by infections. However, a tubercular etiology of this condition is very rare. A review of the literature yielded only a few cases of polyarticular tuberculosis with osteonecrosis in immunosuppressed individuals. No case of monoarticular tubercular osteonecrosis diagno...

Musculoskeletal tuberculosis is known for its ability to present in various forms and guises at different sites. Tubercular spinal epidural abscess (SEA) is an uncommon infectious entity. Its presence without associated osseous involvement may be considered an extremely rare scenario. We present a rare case of tubercular SEA in an immune-competent 35-year-old male patient. The patient presented...

Anti tubercular drug related hepatotoxicity is common. The mechanism of injury and factors predisposing to its development are not fully understood. Forty patients with anti tubercular drugs related hepatotoxicity were studied to see the clinical and biochemical profile of these patients and to find out the significance of acetylator phenotype in the development of hepatotoxicity. Mean age of p...

PURPOSE To report the use of real-time or quantitative polymerase chain reaction (qPCR) in confirming the diagnosis of tubercular uveitis. METHODS A qPCR assay using primers targeting the MPB64 gene of Mycobacterium tuberculosis (MTB) was developed. A standard curve for quantification of mycobacterial load was generated. Vitreous fluid samples from patients presumed to have tubercular uveitis...

Introduction: Tuberculosis is one of the major public health problems in India and most of the other developing countries. Tuberculosis is most common cause of death world over. The deadly synergy between Mycobacterium tuberculosis and AIDS has resulted in resurgence of tuberculosis world over. Tuberculosis is still considered a social disease; it reflects the standard of living in the communit...

Liquefactive necrosis of the lung tissue caused by microbial infection, lung abscess is characterised by formation of cavities containing necrotic debris. In the vast majority of cases of lung abscess, polymicrobial bacteria can be found with predominance of anaerobes. Mycobacterium has been described as a very rare causative agent of community acquired lung abscess. We are presenting a case of...

Allium sativum has been reported to have a lot of therapeutic potentials such as antihypertensive, antimicrobial and hypocholesterolemic. This study has investigated its effect on anti-tubercular drugs hepatotoxicity. Wistar albino rats were pretreated and co-administered orally with aqueous solution of Allium sativum. Eighteen rats were divided into six groups of three rats each. Group 1 were ...