BACKGROUND Combination antiretroviral therapy (cART) has progressively decreased mortality of HIV-associated tuberculosis .To date, however, limited data on tuberculosis treatment outcomes among coinfected patients who are not ART-naive at the time of tuberculosis diagnosis are available. METHODS A multicenter, observational study enrolled 246 HIV-infected patients diagnosed with tuberculosis...

Tuberculosis (TB) is one of the leading causes mortality in developing countries world. It an airborne disease spread through inhaling. This study investigated cases tuberculosis at Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nigeria. The TB data used this are secondary sourced from NAUTH register January 2005 to December 2021. a retrospective cohort and time series analysis all diagnos...

Tuberculosis has long been a public health threat in the Philippines, however, there is still no recent trend study for this country’s morbidity and deaths from said infectious disease. With that, an age-, sex-, region-specific mortality tuberculosis Philippines was conducted these types of studies significantly help surveillance control diseases. Data Philippine Health Statistics 1960 to 2019 ...

BACKGROUND South African guidelines recommend protease-inhibitor-based antiretroviral therapy (ART) with lopinavir-ritonavir for human immunodeficiency virus (HIV)-infected children <36 months of age. We investigated factors associated with viral suppression and mortality among young children initiating ART. METHODS Treatment-naive, ART-eligible, HIV-infected children (aged 6-104 weeks) were ...

Mycobacterium tuberculosis is a pathogenic organism, which causes high morbidity and mortality in human being. The disease tuberculosis is commonly seen in immunocompromised patients. M. tuberculosis takes time to grow on culture medium (Lowenstein-Jensen medium) for drug susceptibility testing to avoid delay, now a day molecular techniques are introduced in many developing countries including ...

Over half a century ago, McKeown and colleagues proposed that economics was a major contributor to the decline of infectious diseases, including respiratory tuberculosis, during the 19th and 20th centuries. Since then, there is no consensus among researchers as to the factors responsible for the mortality decline. Using the case study of the islands of Malta and Gozo, we examine the relationshi...

Tuberculosis is an opportunistic infection with high morbidity and mortality in solid organ transplant patients. The reasons for this high morbidity and mortality lie mostly in diagnostic difficulties, which cause delays in starting treatment, and associated pharmaceutical toxicity. There are still major issues and difficulties in managing tuberculosis in solid organ transplant patients. These ...

BACKGROUND There are limited data measuring the impact of expanded human immunodeficiency virus (HIV) prevention activities on the tuberculosis epidemic at the country level. Here, we characterized the potential impact of the US President's Emergency Plan for AIDS Relief (PEPFAR) on the tuberculosis epidemic in sub-Saharan Africa. METHODS We selected 12 focus countries (countries receiving th...

BACKGROUND Mortality from TB continues to be a global public health challenge. TB ranks alongside Human Immunodeficiency Virus (HIV) as the leading infectious causes of death globally. HIV is a major driver of TB related morbidity and mortality while TB is the leading cause of mortality among people living with HIV/AIDS. We sought to determine excess mortality associated with HIV and the effect...

Tuberculosis is the leading cause of mortality among individuals infected with HIV, killing more than 1000 people every day. Even if they receive treatment for tuberculosis, people with HIV are more likely to die from tuberculosis than people without HIV, especially if they are not receiving antiretroviral therapy or if they have multidrug-resistant tuberculosis. They do not die because we cann...