Metabolic function and architecture of mitochondria are intimately linked. More than 60 years ago, cristae were discovered as characteristic elements of mitochondria that harbor the protein complexes of oxidative phosphorylation, but how cristae are formed, remained an open question. Here we present experimental results obtained with yeast that support a novel hypothesis on the existence of two...

This study applies four different types of machine learning methods to model the power performance behaviour of a tubular solid oxide fuel cells (SOFC) under different operating conditions. The corresponding machine learning methods are: artificial neural network (ANN), fuzzy inference system (FIS), support vector machine (SVM), and genetic programming (GP). By using four types of inputs of the...

Wasp bite induced ATN from direct venom toxicity is very rare. We report two such cases. The first case was a 14 years old boy admitted with oliguria following multiple wasp stings. He had grossly deranged renal function requiring hemodialysis support. The other patient was a 24 years old man admitted with similar history and also required hemodialysis support. Renal biopsy in both cases was co...

we report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. this unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. the tubular functional disturbance appeared to be related to the presence of lam...

The stop-flow method has been used to study various aspects of renal tubular transport mechanisms. According to this method, aldosterone promotes the tubular reabsorption of sodium in the distal tubule. The method also indicates that the secretion of potassium, hydrogen and ammonium occurs in a very distal portion of the nephron. The substitution of anions such as ferrocyanide, sulfate and phos...

A comparison of urinary alpha 1-microglobulin concentrations to the behaviour of other indicators of renal tubular disorders, beta 2-microglobulin, retinol-binding protein and N-acetyl-beta-D-glucosaminidase (NAG) has been made. In acute tubular disorders the concentrations of urinary beta 2M and RBP are highly correlated (r = 0.89) but this is less marked for alpha 1M and beta 2M (r = 0.55) an...

A nonobstructing optical method was developed to measure proximal tubular fluid reabsorption in rat nephron at 0.25 Hz. The effects of uncaging luminal nitric oxide (NO) on proximal tubular reabsorption were investigated with this method. Proximal fluid reabsorption rate was calculated as the difference of tubular flow measured simultaneously at two locations (0.8-1.8 mm apart) along a convolut...

Solid oxide fuel cells that are designed in different geometrical structures (planar, tubular, flat-tubular, etc.) dirt-free, quiet, and efficient run using fuels including contagions fuels. In this work, the performance of a 3D model direct ammonia feed anode supported flat-tubular solid cell having six supply channels was developed, investigated, elucidated numerically comparison with hydroge...

In this paper, Hammerstein model and Nonlinear AutoRegressive with eXogeneous inputs (NARX) model are used to represent tubular heat exchanger. Both models have been identified using least squares support vector machines based algorithms. Both algorithms were able to model the heat exchanger system without requiring any apriori assumptions regarding its structure. The results indicate that the ...