Surgery for advanced ovarian cancer has drastically evolved over the last decades with an increased radicality on multiple levels. Patients high tumor burden, relapsed disease, and previous lines of treatment are now being offered debulking surgery, in effort to prolong their

The identification of novel tumor-interactive chemokines and the associated insights into the molecular and cellular basis of tumor-microenvironment interactions have continued to stimulate the development of targeted cancer therapeutics. Recently, we have identified monocyte chemoattractant protein 1 (MCP-1; CCL2) as a prominent regulator of prostate cancer growth and metastasis. Using neutral...

The sera and circulating immune complexes (CICs) from mice bearing either UV-2237 mm, K-1735 M2, or B16-BL6 were analyzed for antibody isotype distribution during primary tumor growth and spontaneous metastasis. These studies clearly demonstrate that elevated CIC concentrations parallel the initial stages of primary tumor growth; however, the CICs, as well as serum concentration of all immunogl...

melanogenumia occurs in only a small proportion of mela noma patients, usually terminal, who survive long enough to develop the requisite tumor burden. The occurrence in the blood or urine of compounds that are involved in mela nm synthesis (on possibly in pigment hydrolysis) has long provided a theoretical model for an approach to detecting occult metastases and estimating the tumor burden in ...

We studied the value of soluble CD25, CD8, CD23, CD54 and CD44 serum levels as tumor burden markers in lymphoma. Soluble CD25 compared with the others sCD and the usual serum factors (albumin, lactate dehydrogenase, beta 2-microglobulin, uric acid and C-reactive protein), showed the strongest correlation with the Ann Arbor stage and the number of affected localizations. sCD25 level is the most ...

Abstract Glioblastomas (GBM) are Grade IV gliomas that highly aggressive, lethal primary brain tumors. They extremely heterogenous tumors both at a cellular and molecular level, harboring diverse oncogenes mutated tumor suppressor genes with inter- intra-tumor variability in expression patterns. Currently, the presence of GBM cannot be predicted they diagnosed post-surgical resection by histolo...