Lidocaine has been shown to inhibit the invasion and metastasis of breast cancer, but mechanism still remains unclear. This study explored relationship between lidocaine circulating seeding cancer cells from perspective nerve fiber formation. The cell lines MDA-MB-231 4T1 were subcutaneously inoculated in mice simulate tumor self-seeding by cells. was used treat these growth observed. Silver st...

Here we report that B16F10 murine melanoma cells mimic endothelial cell behavior and the angiogenic process in vitro and in vivo. Cord formation in vitro by tumor cells is stimulated by hypoxia and vascular endothelial growth factor (VEGF) and inhibited by antibodies against VEGF and the VEGF KDR receptor (VEGF receptor 2). We define regulation of tumor cell-derived vascular space formation by ...

echinococcus granulosus is considered the major cause of human hydatid cysts. usually the duration of cyst formation is 10-20 years. this period shortens significantly upon rupture of a primary cyst. the literature describes low incidence of primary involvement of ovary as a site of hydatid cyst formation. our case is the first report on ovarian hydatid cyst in iran. a 60-year-old woman was pre...

ovarian mixed germ cell tumors consisting of endodermal sinus tumor and immature teratoma are very rare and have been reported only in a few case reports. here we report a rare mixed germ cell tumor of ovary which was consisted of endodermal sinus tumor and immature teratoma components with an unusual intraabdominal location. patient was a 21 years old girl with the chief compliant of abdominal...

Metastasis is a multistep process requiring tumor cell detachment from the primary tumor and migration to target organs through the lymphatic or blood circulatory systems. Specific organs are predisposed to metastases in certain cancers and the formation of supportive metastatic microenvironment determines tumor cell homing. Such an environment is provided by a pre-metastatic niche that is form...