BACKGROUND Eucalyptus spp. and Pistascia lentiscus are among the Palestinian trees that are traditionally used in folkloric medicine in treating many diseases; leaves of which are thought to have anti-inflammatory, antibacterial and antioxidant effects. The goal of this study is to evaluate the in vitro inhibitory effect of Eucalyptus spp. and Pistascia lentiscus extracts on Lipopolysacaride (L...

Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS) comprising weight loss, sleep disruption depression, which can be blocked by administration TNF-in...

Q fever is a zoonotic bacterial disease caused by Coxiella burnetii. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the defense against infection with this Gram-negative coccobacillus. Theoretically, patients who are treated with anti-TNF-α medications are at risk for developing chronic Q fever. We present two patients who developed Q fever while being treated with anti-TNF-α agent...

BACKGROUND: Airway remodeling in children with bronchial asthma is due to the effect of inflammatory mediators and growth factors on epithelium. Vitamin D (VitD) has immunomodulatory many diseases as asthma. The ant-inflammatory anti-fibrotic role VitD could prevent or improve air way asthmatic patients. AIM: study investigated supplementation expression transforming factor-beta (TGF-β), tumor ...

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

Over the past years, views on role played by tumor necrosis factor α (TNF-α) in body have changed. The aim of this review is to provide updates TNF-α functions various pathological conditions. While working review, authors made search and analysis full-text reviews original articles foreign (English) Russian languages using such databases as eLIBRARY.RU, Google Scholar, Web Science, Scopus PubM...

Abstract Objectives Colon cancer patients were analyzed to compare the effects of surgical trauma on immune function by detecting activation degree cell inflammatory cytokines levels after different procedures. Methods In total, 107 with colon divided into open surgery group and laparoscopic group. Serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), toll-like receptor 4 (TLR4), cluster...

the aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (ghrp-2) and growth hormone (gh) on tumor necrosis factor-α (tnf-α),interleukin-6 (il-6) and inducible nitric oxide synthase (inos) gene expression induced by lps in the mousebrain. thirty-five male nmri mice (25±5 g) were injected through the mouse tail vein with saline,...