objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. aggressive periodontitis (agp) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune res...

objective(s) using herbal medicines as a complementary treatment method is increasing in wide variety of diseases. ms14-an herbal-marine preparation-is reported to have anti-inflammatory and immunomodulatory activities; however, the mechanism underlying its therapeutic effect is not known. macrophages play an important role in host defense mechanisms and carry out their role by producing variou...

background and objectives: coronary artery disease (cad) is regarded as the leading cause of morbidity and mortality around the world. diabetes mellitus (dm) is associated with the development of cad and increased risk of morbidity and mortality. the goal of this study was to assess the association of tumor necrosis factorα (tnf-α) and high sensitivity c-reactive protein (hscrp) with cad severi...

Indian hedgehog protein (Ihh) is evolutionarily conserved and serves important roles in controlling the differentiation of progenitor cells into osteoblasts. Ihh null mutant mice exhibit a failure of osteoblast development in endochondral bone. Although studies have demonstrated that Ihh signaling is a potent local factor that regulates osteoblast differentiation, the specific transcription fac...