نتایج جستجو برای: tumorigenesis antiangiogenesis
تعداد نتایج: 25649 فیلتر نتایج به سال:
The authors of this paper have found that some of the data they reported was incorrect and wish to withdraw the paper from publication. There was a mistake in the clinical information transmitted about the case. The paper was originally published online in NDTPlus Advance Access on 01 06 2011. The authors hereby retract this paper and discourage citations.
Curcumin has diverse biological activities, but is known to undergo rapid metabolism via reduction of vinylic double bonds and phase II conjugation. To prevent reductive metabolism of curcumin, we introduced a methyl group at both C2 and C6 positions (compound 1) or at the C2 position (compound 2) of curcumin, creating steric hindrance on double bonds against metabolizing enzymes. As predicted,...
Among numerous gene therapeutic strategies for cancer treatment, gene transfer by conditionally replicative adenovirus (CRAd) of interferon-gamma (IFN-gamma) may be useful because of the possibility that it will yield IFN-gamma-mediated antiangiogenesis, immune responses, and CRAd-mediated oncolysis. In this study, we constructed a human TERT promoter-mediated oncolytic adenovirus targeting tel...
Cervical cancer remains unique among solid tumor malignancies. Persistent infection with oncogenic subtypes of the human papillomavirus (HPV) results in carcinogenesis, predominantly occurring at the cervical transformation zone where endocervical columnar cells undergo metaplasia to a stratified squamous epithelium. The molecular cascade involving viral oncoproteins, E6 and E7 and their degrad...
Succinate dehydrogenase (SDH) is a multifaceted enzyme for the mitochondria of eukaryotes, which responsible converting succinate to fumarate as component in Krebs cycle. Its dysfunction occurs several malignancies associated with endocrine and epithelial tumors. SDH an enzymatic complex made some subunits. recognized oncometabolite; therefore, discovery mutations can give straight connection b...
The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibros...
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