Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia which underlie its complications, including cognitive impairment. T2dm-associated impairment generally the decrease in at least one domain. However, progression can be slowed appropriate blood glucose control. Hb1Ac candidate of biomarker predicting T2DM-associated This based on...

Abstract Type 2 diabetes mellitus (T2DM), one of the most common chronic metabolic diseases, involves a complex interaction among genetic, epigenetic, and environmental risk factors. The incidence prevalence T2DM are rapidly increasing globally. In recent years, body evidences from both human animal studies have displayed an association between exposure to early unfavorable life factors such as...

the aim was to compare the predictive power for type 2 diabetes mellitus (t2dm) using dynamic change (difference) of metabolic syndrome (ms), difference of fasting plasma glucose (fpg), baseline ms and fpg in cohort study.overall, 3461 subjects were recruited from prevention of multiple metabolic disorders and ms in jiangsu of china study with 3.8 years follow-up. cox proportional-hazards regre...

limiting intracellular enzyme for nicotinamide adenine dinucleotide (NAD) synthesis starting from nicotinamide [1]. The plasma Nampt levels are reported to have correlation with obesity and obese related metabolic disease, such as Type 2 diabetes mellitus (T2DM), cardiovascular diseases [2] and hyperlipidemia [3] due to association with lipoprotein and cholesterol. Therefore, sensitive detectio...

The rising incidence of diabetes has become one the major health problems worldwide. It is especially overburdening low-income countries like Pakistan which ranks 4th in prevalence. purpose this review article to analyze current approach management and highlight its deficiencies. also discusses future strategies that can help reduce disease burden. Information was collected from publications we...

Type 2 diabetes mellitus (T2DM) is a common health problem affects about 285 million and expected to reach 438 million by 2030 worldwide [1-3], Stroke and cardiovascular disorders may be induced by T2DM [3-4]. In addition, vitamin D deficiency is a worldwide epidemic health related problem [5,6] which play an important role in T2DM development [7] cardiovascular disease (CVD) and mortality [8-1...

OBJECTIVE To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis. METHODS T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation betwee...

Energy is required for life on Earth, and it provided by the small organelles of cells called mitochondria, also referred to as cell's powerhouses. Mitochondrial DNA (mtDNA), which grouped into several human mtDNA haplogroups, frequently employed in population genetics identify individuals or communities based mutation sites found comparison with reference sequence (rCRS). Previous studies vari...

BACKGROUND Laparoscopic Roux-en-Y gastric bypass (LRYGB) can dramatically ameliorate type 2 diabetes mellitus (T2DM) in morbidly obese patients. However, there is little evidence supporting the effectiveness of LRYGB in low body mass index (BMI) patients. The study was designed to evaluate the safety and results of LRYGB for achieving T2DM remission in patients with BMI in the range of 25-35 kg...

AIM To discuss type 2 diabetes mellitus (T2DM) medication changes required during the popular 5:2 intermittent energy restriction (IER) diet. METHODS A search was conducted in MEDLINE, EMBASE, AMED, CINAHL and Cochrane library for original research articles investigating the use of very low calorie diets (VLCD) in people with T2DM. The search terms used included "VLCD" or "very low energy die...