lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...

the present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. the prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

BACKGROUND Pressor responses to antihypertensive drugs are not addressed in treatment guidelines although they have been described in various clinical situations. We now report the incidence of pressor responses to initiation of monotherapy using four antihypertensive drug types, and the influence of plasma renin activity (PRA) status, among participants in a worksite-based antihypertensive tre...

abstract  introduction: hypertension is the most prevalent chronic disease encountered by physicians. its prevalence has been reported at 18% in isfahan province. hypertension control decreases the risk of stroke and coronary events by 50% and 15%, respectively. according to the world health organization (who), the rate of blood pressure control stands at 12.5%. effective hypertension control r...

Background: There are different street substance users' communities (SSUCs). Typology of SSUCs in Tehran, Iran was approached in this qualitative study.Methods: Using content analysis and saturation principles, 22 street-outreach workers were recruited and interviewed. Data were analyzed using open, axial, and selective coding.Findings: Three types of SSUCs were identified. SSUCs were different...