Gallstone ileus is a complication of cholelithiasis resulting from a fistula between the gallbladder and the gastrointestinal tract. If sufficiently large, a gallstone may lodge at the narrowest part of the gastrointestinal tract, usually the terminal ileum, and present with small bowel obstruction. Here the authors present the unusual case of an 82-year-old man who developed symptoms and signs...

Many patients with gallstones can be managed expectantly. Generally, only persons with symptoms related to the presence of gallstones (e.g., steady, nonparoxysmal pain lasting four to six hours located in the upper abdomen) or complications (such as acute cholecystitis or gallstone pancreatitis) warrant surgical intervention. Biliary pain is alleviated by cholecystectomy in the majority of case...

The diagnosis of gallstone ileus is occasionally challenging due to the variability of its presentation. We herein present a very rare case of gallstone ileus inducing obstructive jaundice at the afferent loop of Roux-en-Y hepaticojejunostomy after 10 years of bile duct cancer surgery. We describe the case of a 74-year-old Korean woman with obstructive jaundice, treated conservatively. She show...

BACKGROUND Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition of target populations for future therapies. This study aimed to define patterns of gallstone composition and identify demographic predictors of gallstone composition in a large sample of symptomatic gallston...

Cholesterol gallstone formation is a response to interactions between multiple genes and environmental stimuli. To determine the subset of cholesterol gallstone susceptibility (Lith) genes possessed by strains CAST/Ei (susceptible) and 129S1/SvImJ (resistant), we conducted quantitative trait locus (QTL) analyses of an intercross between these strains. Parental strains and F(1) mice of both gend...

Cholelithiasis occurs in 10% of the population, most commonly caused by gallstone formation from bile salt cholesterol hypersaturation. Common presentations include cholecystitis and pancreatitis, yet these two gallstone diseases rarely seem to happen simultaneously. Gallstone pancreatitis occurs when gallstones escape from the gallbladder and become lodged within the common bile duct causing b...

The results allow proposing a novel hypothesis and concept of cholesterol gallstone pathogenesis in man: cholestanol may be responsible for the cholesterol supersaturation of gallbladder bile, aseptic inflammation of the gallbladder mucus and consecutive hypersecretion of glycoprotein mucin, gallbladder hypomotility as well as for the heterogenic nucleation process and precipitation of choleste...

Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years. We analyzed NPC1L1 single nucleotide polymorphisms in Chinese gallstone disease patients to investigate their association with gallstone disease. NPC1L1 mRNA expression was also measured in liver biopsies f...

Background: Autopsies of Egyptian and Chinese mummies have demonstrated the existence of gallstones for at least 3,500 years. Today, gallstones occur commonly, especially in the West and in westernized societies. Gallstone complications include biliary colic, acute cholecystitis, choledocholithiasis, cholangitis, gallstone pancreatitis, and gallstone ileus. Gallstone disease exacts a considerab...

Laparoscopic cholecystectomy (LC) is preferred in the treatment of symptomatic cholecystolithiasis. Gallstone spillage is not uncommon, and there have been reports of associated complications. We report a case of a free intraperitoneal gallstone, left inadvertently during LC, which developed an inflammatory phlegmon with abscess containing gallstone, causing extraluminal compression on the dist...