conclusions coq10 abolished neuropathic pain in cci rats. prevention of cell loss might be attributed to the analgesic effect of coq10. hence, it might be used as a therapeutic intervention for neuropathic pain. background oxidative stress contributes to neuropathic pain. coenzyme q10 (coq10) is used for the treatment of neurodegenerative diseases. however, there is no report regarding the ther...

the aim of this study was to investigate the in vitro developmental competence of isolated pre-antral follicles derived from vitrified ovaries in the presence of coenzyme q 10 (coq 10 ) . mice pre-antral follicles derived from fresh and vitrified-warmed ovarian tissues were in vitro cultured individually in α-mem medium supplemented with or without coq 10 , followed by adding human chorionic go...

Current treatment options for parkinsonism as a neurodegenerative disease are limited and still mainly symptomatic and lack significant disease-modifying effect. Understanding its molecular pathology and finding the cause of dopaminergic cell loss will lead to exploring therapies that could prevent and cure the disease. Mitochondrial dysfunction was found to stimulate releasing of reactive oxyg...

Coenzyme Q10 (CoQ10) is a ubiquitous nutrient in human cells where it is essential for mitrochondrial energy production. CoQ10 exists in both an oxidized (ubiquinone) and reduced form (ubiquinol), with ubiquinol being the bioactive form. In addition to its use in cellular ATP production ubiquinol acts as a powerful lipid-soluble antioxidant that protects lipid membranes and lipoproteins from ox...

The ubiquinone (coenzyme Q) systems of eleven strains of Coccidioides immitis were determined by high performance liquid chromatography (HPLC). The ubiquinone profile of the fungi was shown to be homogeneous: in all of the strains, ubiquinone-10 (Q-10) was demonstrated to be the major component, with Q-9 as a minor component. The results imply that the ubiquinone system may serve as an addition...

Ethanol is a principle ingredient of alcoholic beverages with potential neuronal-genotoxicity, and associated neuronal oxidative DNA damage, neurodegeneration in the CNS and neurocognitive deficits is well documented. Chronic consumption of alcohol is associated with disturbances of mnemonic functions and behavioural deficit. DNA-damaging molecules such as reactive oxygen species (ROS), lipidpe...

Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport ch...

Introduction : Nicotine was assumed to be the cause of compromised flap. The administration antioxidants can eliminate such effect, and one most promising is Coenzyme Q10. research aims find effect orally administered Q10 on viability random skin flaps in nicotine-exposed wistar rats. Method Twenty-seven white rats (Rattus norvegicus) were assigned three groups. first group received no nicotine...

Abstract: Objectives: Diabetes is a major disease that causes tremendous economic burden internationally. To tackle this horrible condition, good therapeutic intervention with nutraceutical required. These include diabetic nephropathy, which ranges from chronic kidney to end-stage renal failure. Thus, study used such coenzyme Q10 and HMG-CoA reductase inhibitor (rosuvastatin) see how beneficial...