The accuracy of a diagnostic test with continuous-scale results is of high importance in clinical medicine. It is often summarised by the area under the ROC curve (AUC). In this article, we discuss and compare nine non-parametric confidence intervals of the AUC for a continuous-scale diagnostic test. Simulation studies are conducted to evaluate the relative performance of the confidence interva...

The objective of this study was to assess the effect of a high-fat meal on the pharmacokinetics of moxidectin. Healthy male subjects were randomized to receive single oral 8 mg doses of moxidectin after an overnight fast or high-fat breakfast. In fasted subjects (N = 27), mean [SD] parameters were C(max): 58.9 [12.5] ng/mL; t(max): 3.7 [1.5] h; area under concentration-time curve (AUC): 3,387 [...

Preliminary -The BERTScope BSX-series Bit Error Rate Tester introduces a receiver test platform capable of supporting emerging Gen4 standards and beyond. With the addition of powerful data processing and internal Tx equalization, the BERTScope supports protocol-based handshaking and synchronization with your device under test (DUT), including interactive link training at data rates up to 32 Gb/...

BACKGROUND Double-blind, placebo-controlled (DBPC) trials are the gold standard for demonstrating clinical efficacy and tolerability. The placebo effect, although an important feature in placebo-controlled studies, has never been systematically investigated in allergen-specific immunotherapy (SIT) studies. This study was performed to examine the placebo response in SIT trials that employed a ba...

PURPOSE Investigate the role of metabolites in bioequivalence (BE) assessment. METHODS. Sets of ordinary differential equations are used to generate concentration - time data for both parent drug (P) and metabolite (M). The calculations include 24 subjects, two different formulations (Test, Reference), and a range of Test/Reference ratios for the fraction of dose absorbed and the rate of absorp...

Omland and colleagues’ paper examining the outcome of IVF in a ‘natural cycle’ model to study aetiological differences between endometriosis and other infertility groups interested us (Omland et al., 2001). Their findings differ from ours and we have tried to understand these differences. It is important to distinguish between this study, which used HCG as a surrogate for the endogenous LH surg...

Estimating the quality of test suites is an important and difficult task. Mutation analysis is one approach to measure test quality by injecting faults in a correct version of the system under test and measuring the percentage of faulty systems that are detected by the tests. There are several automatic mutation analysis tools. Each of them, however, is restricted to a comparatively small range...

BACKGROUND The intranasal (IN) administration of epinephrine could be an alternative route for anaphylaxis treatment. Although IN epinephrine absorption has been demonstrated in animals, such data in humans are still lacking. OBJECTIVE To study the pharmacokinetics of IN epinephrine absorption in humans. METHODS Each healthy adult (n = 5) was administered IN saline, IN epinephrine at variou...

Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cort...