In skeletal muscle, the transcription factors Foxo1 and Foxo3A control expression of proteins that mediate muscle atrophy, making the nuclear concentration and nuclear-cytoplasmic movements of Foxo1 and Foxo3A of therapeutic interest in conditions of muscle wasting. Here, we use Foxo-GFP fusion proteins adenovirally expressed in cultured adult mouse skeletal muscle fibers to characterize the ti...

Nerve diseases including acute injury such as peripheral nerve injury (PNI), spinal cord injury (SCI) and traumatic brain injury (TBI), and chronic disease like neurodegeneration disease can cause various function disorders of nervous system, such as those relating to memory and voluntary movement. These nerve diseases produce great burden for individual families and the society, for which a lo...

We study elasto-plastic deformations of unidirectional fiber reinforced polymeric composites (UFPCs) with fibers assumed to deform elastically and the matrix elasto-plastically. The matrix’s and hence composite’s plastic deformations are analyzed by using both the pressure-independent von Mises yield surface and the pressure-dependent Drucker–Prager yield surface and the associated flow rules. ...

Unidirectional chloride-36 fluxes were measured in internally dialyzed barnacle giant muscle fibers. About 50--60% of the Cl efflux was irreversibly blocked by the amino-group reactive agent, 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulfonic acid (SITS), when it was applied either intra- or extracellularly. Similarly, Cl influx was also blocked by SITS. No significant effect on [Cl]i of SITS...

We report on the experimental observation of temporal anti-dark solitons in optical fibers. Under suitable condition average dynamics light propagation a unidirectional fiber ring laser is governed by nonlinear Schrödinger equation (NLSE). Dark were found net normal cavity dispersion region. further show experimentally that at near zero dispersion, where third-order plays role, either dark soli...

The polymerization of many amyloids is a two-stage process initiated by the formation of a seeding nucleus or protofibril. Soluble protein then assembles with these nuclei to form amyloid fibers. Whether fiber growth is bidirectional or unidirectional has been determined for two amyloids. In these cases, bidirectional growth was established by time lapse atomic-force microscopy. Here, we invest...

The influence of high-temperature argon heat-treatment on the microstructure and room- temperature in-plane tensile properties 2D woven CVI unidirectional MI SiC/SiC composites with Hi-Nicalon™-S SiC fibers was investigated. were heat-treated between 1200 1600 °C for 1- 100-hr, 1315 1400 up to 2000 hr. In addition, fast fracture strengths these also measured in air. Both exhibited different deg...

This paper presents a study of the electrical and mechanical behavior of several continuous carbon fibers epoxy composites for both strengthening and monitoring of structures. In these composites, the arrangement of fibers was deliberately diversified to test and understand the ability of the composites for self-sensing low strains. Composites with different arrangements of fibers and textile w...