The aim of present study was to establish the relationship between level blood serum cytokines and indexes pulmonary function as well identify markers evolving dysfunction small airways in obese patients with partially controlled mild bronchial asthma. We have examined 53 asthma clinical course complicated obesity (I-II degree). control group consisted 25 healthy volunteers. All participants un...

Microplastics are tiny plastic debris in the environment from industrial processes, various consumer items, and breakdown of waste. Recently, microplastics have been found for first time airways, which increases concern about long-term exposure corresponding impacts on respiratory health. To date, a precise understanding microplastic transport to airways is missing literature. Therefore, this f...

The branching network of airways in the lung poses a complex challenge to both physiologists and physicians. Measurements of lung function have been made for nearly 200 years. Davy (1800) and Hutchinson (1844) were amongst the first to recognise and measure lung volumes. Despite these early discoveries, progress in understanding pulmonary physiology was intermittent. Rohrer (1925) and Rahn (194...

Allergic asthma is a complex disease characterized by acute inflammation of the airways that over time leads to the development of significant structural changes termed remodeling. TNF-related apoptosis-inducing ligand (TRAIL) has an important regulatory role in acute allergic airways inflammation through up-regulation of the E3 ubiquitin ligase Midline-1 (MID-1), which limits protein phosphata...

Managing the airway of a critically injured trauma patient in the prehospital environment is challenging, especially when access to the patient's airway is limited as is often the case in vehicle entrapment incidents. This paper reports the use of the laryngeal mask airway as an adjunct to airway management when attempts using simple airway management techniques have failed to provide adequate ...

Nitric oxide is endogenously released in the airways by nitric oxide synthase. Functionally, two isoforms of this enzyme exist: constitutive and inducible. The former seems to protect airways from excessive bronchoconstriction while the latter has a modulatory role in inflammatory disorders of the airways such as asthma. This review explores the physiological and pathophysiological role of endo...

The relationship between the F.E.V.(1) as an index of airways obstruction and Pco(2) as an index of hypoventilation was investigated in 13 patients with chronic obstructive airways disease. Patients who had a normal Pco(2) despite severe airways obstruction retained relatively normal sensitivity to CO(2) as assessed by their "inspiratory mechanical work rate" response to CO(2). Others showed a ...

bstruction of the central airways, the trachea and main stem bronchi, may result from many disease processes including malignant growths. It is estimated that in the United States, malignant neoplasms will cause central airway obstruction (CAO) in 80,000 cancer patients a year.1 It is estimated that 20% of these patients will experience significant morbidity due to persistent cough, dyspnea, an...

OBJECTIVE To assess the sensitivity of noninvasive virtual bronchoscopy based on multirow detector CT scanning in detecting and grading central and segmental airway stenosis using flexible bronchoscopic findings as the reference standard. MATERIALS AND METHODS In a blinded controlled trial, multirow detector CT virtual bronchoscopy and flexible bronchoscopy were used to search for and grade a...

The authors performed bronchoscopic examination using an ultrathin bronchoscope to determine the characteristics of the peripheral airways in chronic obstructive pulmonary disease (COPD). The study population comprised 13 healthy control subjects, 10 patients with chronic bronchitis without airflow limitation, and 20 patients with COPD. The COPD patients were divided clinically into 10 with chr...